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首页> 外文期刊>The European Journal of Neuroscience >Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus.
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Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus.

机译：电生理学证据表明，内侧前额叶皮层和外侧ha管的输入汇聚在背ra核的单个神经元上。

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Neuronal projections to the dorsal raphe nucleus (DRN) from the medial prefrontal cortex (mPFC) and lateral habenula nucleus (LHb) provide the two key routes by which information processed by mood regulatory, cortico-limbic-striatal circuits input into the 5-HT system. These two projections may converge as it appears that both activate local GABAergic neurons to inhibit 5-HT neurons in the DRN. Here we have tested this hypothesis by measuring the effect of stimulation of the mPFC and LHb on the activity of 5-HT and non-5-HT, putative gamma-amino butyric acid (GABA) neurons in the DRN using extracellular recordings in anaesthetized rats. A total of 119 5-HT neurons (regular, slow firing, broad spike width) and 21 non-5-HT, putative GABA neurons (fast-firing, narrow spike width) were tested. Electrical stimulation of the mPFC or LHb caused a poststimulus inhibition (30 ms latency) of 101/119 5-HT neurons, of which 61 (60%) were inhibited by both the mPFC and LHb. Electrical stimulation of the mPFC or LHbalso caused a short latency (12-20 ms) poststimulus facilitation of 10/21 non-5-HT neurons, of which 5 (50%) were activated by both the mPFC and LHb. These data indicate that a significant number of 5-HT neurons and non-5-HT neurons in the DRN are influenced by both the mPFC and LHb. Moreover, the data are compatible with the hypothesis and that there is a convergence of mPFC and LHb inputs on local circuit GABAergic neurons in the DRN which in turn inhibit the activity of 5-HT neurons.
机译：内侧前额叶皮层（mPFC）和外侧ha核（LHb）对背沟核（DRN）的神经元投射提供了两条主要途径，通过这些途径，情绪调节，皮质-边缘-纹状体回路输入到5-HT系统。这两个预测可能会收敛，因为它们似乎都激活了局部GABA能神经元以抑制DRN中的5-HT神经元。在这里，我们通过使用麻醉大鼠的细胞外记录来测量mPFC和LHb刺激对DRN中5-HT和非5-HT推定的γ-氨基丁酸（GABA）神经元活性的影响，从而检验了这一假设。 。总共测试了119个5-HT神经元（正常，缓慢发射，宽尖峰宽度）和21个非5-HT假定的GABA神经元（快速发射，窄尖峰宽度）。 mPFC或LHb的电刺激引起101/119个5-HT神经元的刺激后抑制（30 ms潜伏期），其中61个（60％）被mPFC和LHb抑制。 mPFC或LHb的电刺激还引起10/21个非5-HT神经元刺激后的短暂潜伏期（12-20 ms），其中5个（50％）被mPFC和LHb激活。这些数据表明，DRN中大量的5-HT神经元和非5-HT神经元受mPFC和LHb的影响。此外，数据与假设相符，并且在DRN的局部回路GABA能神经元上存在mPFC和LHb输入的收敛，进而抑制了5-HT神经元的活性。

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