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首页> 外文期刊>The European Journal of Neuroscience >Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat.
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Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat.

机译：杏仁核-肠胃内通路在恐惧调节大鼠中的激活。

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Several studies implicate a role for the amygdala in processing of emotional memories that might partially occur in the connections between the amygdala and the hippocampal-parahippocampal areas. The present study was designed to determine if the pathway from the amygdala to the entorhinal cortex becomes activated during acquisition of fear-conditioning. First, the retrograde tracer Fluoro-Gold (FG) was iontophoresed into the entorhinal cortex in rats. Following habituation, animals were divided into five groups: (i) controls that received another habituation session; (ii) animals given a tone only; (iii) animals given a footshock only; (iv) animals given an unpaired presentation of a shock and a tone; and (v) conditioned animals that received a single tone-footshock pairing. Then double-immunohistochemistry against c-Fos and FG or glutamate decarboxylase (GAD67) was performed. The numbers and densities of labelled neurons were calculated in the lateral and basal nuclei of the amygdala. In conditioned animals the number and density of c-Fos-positive nuclei increased in dorsolateral and medial divisions of the lateral nucleus compared with the control group (P < 0.05). Additionally, in the medial division of the lateral nucleus, the percentage of c-Fos/FG double-labelled neurons was higher in the conditioned animals compared with the other groups (P < 0.05). Only a very few GAD67-positive interneurons expressed c-Fos. These data indicate that a part of the amygdalo-entorhinal pathway is activated during acquisition of fear-conditioning. These data support the idea that emotionally relevant sensory information in the lateral nucleus can influence information processing in the hippocampal and parahippocampal areas via the amygdalo-entorhinal pathway.
机译：几项研究暗示杏仁核在处理情绪记忆中可能起着一定作用，而情绪记忆可能部分发生在杏仁核与海马-海马旁区域之间的联系中。本研究旨在确定在获取恐惧条件期间从杏仁核到内嗅皮层的途径是否被激活。首先，将逆行示踪剂氟金（FG）离子电渗入大鼠的内嗅皮层。习惯化后，将动物分为五组：（i）接受另一次习惯化训练的对照组; （ii）只给动物以声调的动物; （iii）仅受到足部震动的动物; （iv）动物以不成对的形式表现出震惊和语气; （v）条件动物接受了一次单音-休克配对。然后进行针对c-Fos和FG或谷氨酸脱羧酶（GAD67）的双重免疫组织化学。计算杏仁核的外侧核和基底核中标记神经元的数量和密度。与对照组相比，在条件动物中，c-Fos阳性核的数量和密度在外侧核的外侧和内侧分区增加（P <0.05）。此外，在外侧核的内侧分隔中，条件动物中的c-Fos / FG双标记神经元百分比高于其他组（P <0.05）。只有极少的GAD67阳性中间神经元表达c-Fos。这些数据表明，在获取恐惧条件期间，杏仁核-肠胃内通路的一部分被激活。这些数据支持这样的想法，即在外侧核中与情感相关的感觉信息可以通过杏仁核-肠胃内途径影响海马和海马旁区域的信息处理。

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