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首页> 外文期刊>The European Journal of Neuroscience >Early (E12) cortical progenitors can change their fate upon heterotopic transplantation.
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Early (E12) cortical progenitors can change their fate upon heterotopic transplantation.

机译：早期（E12）皮质祖细胞可以在异位移植后改变命运。

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摘要

To help understand how the cortical map is set up during the early stages of corticogenesis, we have examined the developmental fate of embryonic day (E) 12 cortical progenitors in the rat. We have analysed the pattern of thalamic connections and cytoarchitectonic organization developed by progenitor cells removed at E12 from the presumptive parietal or occipital cortex and grafted into the parietal cortex of newborn hosts. Occipital progenitors grafted into the parietal cortex differentiated into neurons that developed reciprocal connections with the ventrobasal complex of the host thalamus. They could also form barrel-like structures, within which axons of the ventrobasal complex were distributed in dense patches. Some of these barrel-like structures were arranged in rows. Moreover, these progenitors failed to develop characteristic traits of occipital cortex cells as they did not establish connections with the dorsal lateral geniculate nucleus. We propose that cortical progenitors are not committed at E12 and, upon heterotopic transplantation, have the capacity to respond to local cues and to subsequently differentiate and maintain major phenotypic characteristics of neurons in their new environment. Only early progenitors are multipotent. By E13/E14, indeed, most cortical cells become irreversibly committed and upon heterotopic transplantation differentiate neurons with phenotypic characteristics of their cortical site of origin (Pinaudeau et al., 2000, Eur. J. Neurosci., 12, 2486-2496).
机译：为了帮助了解如何在皮质发生的早期阶段建立皮质图谱，我们检查了大鼠胚胎天（E）12个皮质祖细胞的发育命运。我们已经分析了由假定的顶叶或枕叶皮层的E12处去除的祖细胞并移植到新生宿主的顶叶皮层中的祖细胞形成的丘脑连接和细胞结构组织的模式。移植到顶叶皮层的枕骨祖细胞分化为神经元，这些神经元与宿主丘脑的腹基底复合体发展了相互联系。它们还可以形成桶状结构，其中脑室基底突的轴突分布在密集的斑块中。这些桶状结构中的一些排列成行。此外，这些祖细胞未能建立枕叶皮层细胞的特征性特征，因为它们未与背外侧膝状核建立联系。我们建议皮质祖细胞不致力于E12，并在异位移植后，有能力对局部线索作出反应，并随后在其新环境中区分和维持神经元的主要表型特征。仅早期祖细胞是多能的。实际上，通过E13 / E14，大多数皮质细胞变得不可逆转地定型，并且在异位移植后，分化出具有其皮质起源位点的表型特征的神经元（Pinaudeau等，2000，Eur.J.Neurosci。，12，2486-2496）。

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