...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >VEGF is necessary for exercise-induced adult hippocampal neurogenesis.
【24h】

VEGF is necessary for exercise-induced adult hippocampal neurogenesis.

机译：VEGF是运动诱发的成人海马神经发生所必需的。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Declining learning and memory function is associated with the attenuation of adult hippocampal neurogenesis. As in humans, chronic stress or depression in animals is accompanied by hippocampal dysfunction, and neurogenesis is correspondingly down regulated, in part, by the activity of the hypothalamic-pituitary-adrenal axis as well as glutamatergic and serotonergic networks. Antidepressants can reverse this effect over time but one of the most clinically effective moderators of stress or depression and robust stimulators of neurogenesis is simple voluntary physical exercise such as running. Curiously, running also elevates circulating stress hormone levels yet neurogenesis is doubled in running animals. In evaluating the signalling that running provides to the central nervous system in mice, we have found that peripheral vascular endothelial growth factor (VEGF) is necessary for the effects of running on adult hippocampal neurogenesis. Peripheral blockade of VEGF abolished running-induced neurogenesis but had no detectable effect on baseline neurogenesis in non-running animals. These data suggest that VEGF is an important element of a 'somatic regulator' of adult neurogenesis and that these somatic signalling networks can function independently of the central regulatory networks that are typically considered in the context of hippocampal neurogenesis.
机译：学习记忆功能的下降与成人海马神经发生的减弱有关。与人类一样，动物的慢性应激或抑郁症伴有海马功能障碍，神经发生相应地受到下丘脑-垂体-肾上腺轴的活性以及谷氨酸能和血清素能网络的调节。抗抑郁药可以随着时间的推移逆转这种作用，但临床上最有效的压力或抑郁调节剂之一，也是神经发生的有力刺激剂，是简单的自愿性体育锻炼，例如跑步。奇怪的是，跑步还可以提高循环应激激素水平，但跑步动物的神经发生能力却翻了一番。在评估跑步向小鼠中枢神经系统提供的信号时，我们发现外周血管内皮生长因子（VEGF）对于跑步对成年海马神经发生的影响是必需的。 VEGF的周围阻滞消除了跑步引起的神经发生，但对非跑步动物的基线神经发生没有可检测的影响。这些数据表明，VEGF是成人神经发生的“体细胞调节剂”的重要组成部分，并且这些体细胞信号网络可以独立于通常在海马神经发生的背景下所考虑的中央调节网络起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号