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首页> 外文期刊>The European Journal of Neuroscience >Convergent responses of Barrington's nucleus neurons to pelvic visceral stimuli in the rat: a juxtacellular labelling study.
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Convergent responses of Barrington's nucleus neurons to pelvic visceral stimuli in the rat: a juxtacellular labelling study.

机译：Barrington核神经元对大鼠盆腔内脏刺激的收敛反应：近细胞标记研究。

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Barrington's nucleus impacts on bladder and distal colon function and relays pelvic visceral information to the forebrain. This study investigated processing of information from the bladder and the distal colon by Barrington's nucleus in the rat. The responses of individual Barrington's nucleus neurons to bladder and/or colon distention were characterized using extracellular recording and the recorded neurons were identified using juxtacellular labelling. Most neurons within Barrington's nucleus (79%) were activated by bladder distention, consistent with its role as a pontine micturition centre. Although no neurons were selectively responsive to colon distention, the majority of bladder-responsive neurons (73%) were also activated by colon distention. In a second study, Barrington's nucleus neurons were characterized with respect to their response to colon distention and their immunoreactivity for the stress-related neuropeptide corticotropin-releasing factor (CRF). Of 30 labelled neurons in the central part of Barrington's nucleus, 53% were activated by colon distention and 63% of these were CRF-ir. This is the first report demonstrating that Barrington's nucleus neurons are responsive to colon distention. The results provide evidence for convergence of information from the bladder and the colon onto individual Barrington's nucleus neurons. Taken with evidence that many Barrington's nucleus neurons are synaptically linked to the bladder and colon, the present study suggests a role for these neurons in coordinating peripheral parasympathetic and central responses to both viscera and implicate CRF as a neurotransmitter in this function. Dysfunctions in this circuit may underlie the coexistence of colon and bladder symptoms observed in functional bowel disorders.
机译：巴灵顿核会影响膀胱和结肠远端功能，并将盆腔内脏信息传递到前脑。这项研究调查了大鼠巴灵顿核对膀胱和远端结肠信息的处理。使用细胞外记录来表征单个Barrington核神经元对膀胱和/或结肠扩张的反应，并使用并列细胞标记来识别记录的神经元。 Barrington核内的大多数神经元（79％）被膀胱扩张激活，与其作为桥脑排尿中心的作用相一致。尽管没有神经元对结肠扩张有选择性反应，但大多数膀胱反应性神经元（73％）也被结肠扩张激活。在第二项研究中，Barrington核神经元的特征是它们对结肠扩张的反应及其对应激相关神经肽促肾上腺皮质激素释放因子（CRF）的免疫反应性。在巴灵顿核中部的30个标记神经元中，有53％被结肠扩张激活，其中63％是CRF-ir。这是第一份证明巴灵顿核神经元对结肠扩张有反应的报告。结果为从膀胱和结肠到单个Barrington核神经元的信息融合提供了证据。有证据表明，许多巴灵顿核神经元与膀胱和结肠突触连接，本研究表明这些神经元在协调对内脏的外周副交感神经和中枢反应中的作用，并暗示CRF作为这种功能的神经递质。在功能性肠病中观察到的结肠和膀胱症状并存可能是该回路功能障碍的基础。

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