p53 inactivation leads to impaired motor synchronization in mice.

Campana AL; Rondi Reig L; Tobin C; Lohof AM; Picquet F; Falempin M; Weitzman JB; Mariani J

首页> 外文期刊>The European Journal of Neuroscience >p53 inactivation leads to impaired motor synchronization in mice.

【24h】

p53 inactivation leads to impaired motor synchronization in mice.

机译：p53失活导致小鼠运动同步受损。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We have combined genetic and pharmacological approaches to investigate the behavioural consequences of inactivation of the murine p53 protein. Our behavioural analysis revealed that p53-null mice (p53KO) exhibit a very specific and significant motor deficit in rapid walking synchronization. This deficit, observed using the rotarod test, was the only behavioural defect of p53KO mice. We demonstrated that it was not due to an increase in neuronal number or abnormal connectivity in the olivo-cerebellar system, thought to control motor synchronization. In order to test the role of p53 in the central nervous system, we injected a pharmacological inhibitor of p53 activation, pifithrin-alpha, into the cerebellum of wild-type mice. This treatment mimicked the walking synchronization deficit of p53KO mice, suggesting that presence of p53 protein in the cerebellum is necessary to execute this synchronization of walking. Our investigation reveals a functional role of cerebellar p53 protein in adult walking synchronization.

机译：我们已经结合了遗传和药理学方法来研究灭活鼠p53蛋白的行为后果。我们的行为分析表明，p53无效的小鼠（p53KO）在快速步行同步过程中表现出非常特异性和显着的运动缺陷。使用旋转脚架试验观察到的这种缺陷是p53KO小鼠的唯一行为缺陷。我们证明这不是由于小脑小脑系统中神经元数目的增加或连接异常，而被认为是控制运动同步的原因。为了测试p53在中枢神经系统中的作用，我们向野生型小鼠小脑中注射了p53活化的药理抑制剂pifithrin-alpha。这种治疗模仿了p53KO小鼠的步行同步缺陷，表明小脑中p53蛋白的存在对于执行这种步行同步是必要的。我们的研究揭示了小脑p53蛋白在成人步行同步中的功能作用。

著录项

来源
《The European Journal of Neuroscience》 |2003年第10期|共12页
作者
Campana AL; Rondi Reig L; Tobin C; Lohof AM; Picquet F; Falempin M; Weitzman JB; Mariani J;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Lameness; Animal; Motor Neurons; Protein p53; Toluene; Thiazoles; pifithrin; 跛行; 动物; 运动神经元; 蛋白质P53; 甲苯;

机译：Lameness;Animal;Motor Neurons;Protein p53;Toluene;Thiazoles;pifithrin;跛行;动物;运动神经元;蛋白质P53;甲苯;

相似文献

外文文献
中文文献
专利

1. p53 inactivation leads to impaired motor synchronization in mice. [J] . Campana AL, Rondi Reig L, Tobin C, The European Journal of Neuroscience . 2003,第10期

机译：p53失活导致小鼠运动同步受损。
2. Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice. [J] . DelBove J, Kuwahara Y, Mora Blanco EL, Molecular Carcinogenesis . 2009,第12期

机译：SNF5的失活与p53丢失合作，以加速Snf5（+/-）; p53（+/-）小鼠的肿瘤形成。
3. Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 during DNA Damage in Acute Myeloid Leukemia Cells [J] . Juni Chakraborty, Shuvomoy Banerjee, Pallab Ray, The Journal of biological chemistry . 2010,第期

机译：由于延长的P53损伤导致细胞适应的增益导致从P53到P73在急性髓性白血病细胞中的DNA损伤期间的功能切换
4. Synergism between magnetic fields and lead overload on the permeability of the blood brain barrier in mice. [C] . M. Perez-Calvo, B. Ribas-Ozonas International conference on computational methods in electrical engineering and electromagnetics . 2003

机译：磁场之间的协同作用与小鼠血脑屏障渗透性的铅过载。
5. Effect ofp53 loss,p53 mutation and aflatoxin exposure on the control of hepatocyte proliferation in transgenic mice. [D] . Yang, Chuanwei (Paul). 2001

机译：p53缺失，p53突变和黄曲霉毒素暴露对控制转基因小鼠肝细胞增殖的影响。
6. Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 during DNA Damage in Acute Myeloid Leukemia Cells [O] . Juni Chakraborty, Shuvomoy Banerjee, Pallab Ray, 2010

机译：急性髓细胞白血病细胞DNA损伤期间由于p53受损时间延长导致的细胞适应性增益导致从p53到p73的功能转换
7. Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. [O] . Simone Jörs, Christian Grimm, Lars Becker, 2010

机译：Trpml3的遗传失活不会导致小鼠的听力和前庭损伤。

p53 inactivation leads to impaired motor synchronization in mice.

摘要

著录项

相似文献

相关主题

期刊订阅