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首页> 外文期刊>The European Journal of Neuroscience >The pattern of ocular dominance columns in cat primary visual cortex: intra- and interindividual variability of column spacing and its dependence on genetic background.
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The pattern of ocular dominance columns in cat primary visual cortex: intra- and interindividual variability of column spacing and its dependence on genetic background.

机译：猫主要视觉皮层中眼支配柱的模式：柱间距的个体内和个体间变异及其对遗传背景的依赖性。

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摘要

We present a comprehensive analysis of the intrinsic variability of the periodicity of ocular dominance columns in cat primary visual cortex (area 17) and its relationship to genetic background and visual experience. We characterized the intra-areal and interindividual variability of column spacing in a large set (n = 49) of ocular dominance patterns adapting a recently developed technique for the two-dimensional analysis of orientation column patterns. Patterns were obtained from three different cat colonies (termed F, M and D), the cats having either normal visual experience or experimentally induced strabismus. Two-dimensional maps of local column spacing were calculated for every pattern. In individual cortices, local column spacings varied by > 50% with the majority of column spacings ranging between 0.6 and 1.5 mm in different animals. In animals from colonies F and M (n = 29), the mean column spacing ranged between 1.03 and 1.27 mm and exhibited no significant differences, either between the twobreeds or between strabismic and normal animals. The mean spacing was moderately clustered in the left and right brain hemisphere of individual animals but not in littermates. In animals from colony D (n = 2), average column spacing ranged between 0.73 and 0.95 mm, and was thus significantly different from the distribution of spacings in animals from breeds F and M, suggesting an influence of genetic factors on the layout of ocular dominance columns. Local column spacing exhibited a considerable systematic intra-areal variation, with largest spacings along the representation of the horizontal meridian and smallest spacings along the peripheral representation of the vertical meridian. The total variability of ocular dominance column spacing comprised 24% systematic intra-areal variation, 18% interindividual differences of mean column spacing and 58% nonsystematic intra-areal variability.
机译：我们目前对猫主要视觉皮层（区域17）中眼优势列周期性的内在变异性及其与遗传背景和视觉体验的关系进行了全面分析。我们表征了大范围（n = 49）的眼部优势模式中列间距的区域内和个体间差异，从而适应了针对定向列模式的二维分析的最新开发技术。从三个不同的猫群（称为F，M和D）获得模式，这些猫具有正常的视觉体验或实验诱发的斜视。为每个模式计算局部列间距的二维图。在单个皮质中，局部柱间距变化> 50％，不同动物中大多数柱间距在0.6到1.5 mm之间。在来自F和M菌落的动物（n = 29）中，平均柱间距在1.03和1.27 mm之间，并且在两种犬之间或斜视和正常动物之间均没有显示出显着差异。平均间距在个别动物的左右脑半球中适度聚集，而在同窝动物中则没有。在D种群（n = 2）的动物中，平均柱距在0.73和0.95 mm之间，因此与F和M品种的动物的柱距分布明显不同，这表明遗传因素对眼球的布局有影响优势列。局部柱间距表现出相当大的系统区域内变化，沿水平子午线的表示具有最大的间距，而沿垂直子午线的外围表示具有最小的间距。优势眼柱间距的总变异性包括24％的系统区域内变异，18％的平均柱间距个体间差异和58％的非系统性区域内变异。

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