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首页> 外文期刊>The European Journal of Neuroscience >Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes.
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Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes.

机译：缺乏连接蛋白30的小鼠在野外表现出增加的情绪和饲养活动以及神经化学变化。

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摘要

Gap-junction channels in the brain, formed by connexin (Cx) proteins with a distinct regional/cell-type distribution, allow intercellular electrical and metabolic communication. In astrocytes, mainly the connexins 43, 26 and 30 are expressed. In addition, connexin30 is expressed in ependymal and leptomeningeal cells, as well as in skin and cochlea. The functional implications of the astrocytic gap-junctional network are not well understood and evidence regarding their behavioural relevance is lacking. Thus, we have tested groups of Cx30-/-, Cx30+/-, and Cx30+/+ mice in the open-field, an object exploration task, in the graded anxiety test and on the rotarod. The Cx30-/- mice showed reduced exploratory activity in terms of rearings but not locomotion in the open-field and object exploration task. Furthermore, Cx30-/- mice exhibited anxiogenic behaviour as shown by higher open-field centre avoidance and corner preference. Graded anxiety test and rotarod performance was similar across groups. The Cx30-/- mice had elevated choline levels in the ventral striatum, possibly related to their aberrant behavioural phenotypes. The Cx30+/- mice had lower dopamine and metabolite levels in the amygdala and ventral striatum and lower hippocampal 5-hydroxyindole acid (5-HIAA) concentrations relative to Cx30+/+ mice. Furthermore, the Cx30+/- mice had lower acetylcholine concentrations in the ventral striatum and higher choline levels in the neostriatum, relative to Cx30+/+ mice. Our data suggest that the elimination of connexin30 can alter the reactivity to novel environments, pointing to the importance of gap-junctional signalling in behavioural processes.
机译：由连接蛋白（Cx）蛋白质形成的大脑中的间隙连接通道具有明显的区域/细胞类型分布，可实现细胞间电和代谢通讯。在星形胶质细胞中，主要表达连接蛋白43、26和30。另外，连接蛋白30在室管膜和软脑膜细胞以及皮肤和耳蜗中表达。星形胶质细胞间隙连接网络的功能含义尚不十分清楚，并且缺乏有关其行为相关性的证据。因此，我们在分级焦虑测试和旋转脚架上，在野外探索对象的任务中，对Cx30-/-，Cx30 +/-和Cx30 + / +小鼠进行了测试。 Cx30-/-小鼠在饲养方面表现出降低的探索活动，但在野外和物体探索任务中却没有运动。此外，Cx30-/-小鼠表现出焦虑发生行为，如较高的开阔视野中心回避和角落偏爱所显示。两组之间的分级焦虑测试和轮岗表现相似。 Cx30-/-小鼠腹侧纹状体胆碱水平升高，可能与其异常的行为表型有关。与Cx30 + / +小鼠相比，Cx30 +/-小鼠的杏仁核和腹侧纹状体的多巴胺和代谢物水平较低，海马5-羟吲哚酸（5-HIAA）浓度较低。此外，相对于Cx30 + / +小鼠，Cx30 +/-小鼠腹侧纹状体的乙酰胆碱浓度较低，新纹状体中的胆碱水平较高。我们的数据表明，连接蛋白30的消除可以改变对新型环境的反应性，指出间隙连接信号在行为过程中的重要性。

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