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首页> 外文期刊>The European Journal of Neuroscience >Subpial neuronal migration in the medulla oblongata of Pax-6-deficient rats.
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Subpial neuronal migration in the medulla oblongata of Pax-6-deficient rats.

机译：Pax-6缺陷大鼠的延髓延髓中的皮下神经元迁移。

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摘要

In rat fetuses, neurons generated in the lower rhombic lip on embryonic day 14 (E14) specifically express the transcription factor Pax-6 and migrate circumferentially in the subpial region along axons which are immunoreactive for TAG-1, a neural cell adhesion molecule. These neurons ultimately settle from E17 in the contralateral medulla oblongata to form the precerebellar nuclei, the lateral reticular and external cuneate nuclei. We have examined this migratory process in rat small eye (rSey2) which has a mutation in the Pax-6 gene. Both the migration and settlement of neurons labelled with 5-bromo-2'-deoxyuridine (BrdU) at E14 delayed in the mutant. Furthermore, in the ventrolateral part of the E16 mutant medulla oblongata, cells both expressing Pax-6 mRNA and prelabelled with BrdU at E14 were ectopically localized in the deep zone of the medullary parenchyma in addition to the normal subpial location. These ectopic neurons remained in close contact with ectopic TAG-1-immunoreactive axons. These results indicate that Pax-6 plays a role in the migration of medullary precerebellar neurons, although neurons generated in the lower rhombic lip can nevertheless migrate and settle to form the external cuneate nucleus in the absence of Pax-6.
机译：在大鼠胎儿中，胚胎第14天（E14）在菱形下唇中产生的神经元特异性表达转录因子Pax-6，并沿着轴突沿圆周在皮下膜区域迁移，该轴突对TAG-1（一种神经细胞粘附分子）具有免疫活性。这些神经元最终从E17在对侧延髓形成，形成小脑前核，网状外侧和楔形外核。我们已经在大鼠小眼（rSey2）中检查了这种迁移过程，该小眼在Pax-6基因中具有突变。在突变体中，在E14处被5-溴2'-脱氧尿苷（BrdU）标记的神经元的迁移和沉降均被延迟。此外，在E16突变型延髓延髓的腹侧部分，除了正常的椎管旁位置外，在Pa14处均表达Pax-6 mRNA并预先标记有BrdU的细胞异位定位在髓质实质的深处。这些异位神经元仍与异位TAG-1-免疫反应性轴突保持紧密接触。这些结果表明，尽管在没有Pax-6的情况下，下菱形唇中生成的神经元仍可以迁移并沉降以形成楔形外核，但是Pax-6在延髓小脑前神经元的迁移中起作用。

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