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首页> 外文期刊>The European Journal of Neuroscience >5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat.
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5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat.

机译：5-HT1A受体参与了5-HT诱导的慢性脊髓大鼠运动功能恢复的短期和长期过程。

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摘要

After thoracic spinal cord transection, a paraplegic syndrome occurs. Previous data showed that an acute administration of a 5-HT2 agonist (quipazine) could promote motor function recovery in spinal rats. However, continuous subdural perfusion of quipazine via an osmotic pump over 1 month proved to be more effective. The present study was designed to investigate the possible involvement of 5-HT1A receptors in such recovery. Motor performances and locomotor parameters were analysed in spinal animals receiving daily, for 1 month, a dose of the 5-HT1A agonist 8-OHDPAT. The results were compared to those obtained in spinal rats receiving either a placebo or quipazine in the same conditions. Using daily injections instead of continuous perfusion of either receptor agonist to spinal animals allowed characterization of short- and long-term consequences of pharmacological stimulation of 5-HT1A and 5-HT2 receptors on motor function recovery. Our data demonstrate that daily injections of a 5-HT1A agonist induce long-term, cumulative, positive effects on motor function recovery, as assessed by the improvement in the walking parameters observed before the 'day-test' injection. This might involve use-dependent processes depending on a chronic and/or repetitive stimulation of the spinal network for locomotion in relation to 5-HT receptor activation. A further improvement in the motor parameters, transiently observed following the injection, suggests a more direct action of 5-HT1A and 5-HT2 receptor activation on spinal neurons involved in motor pattern generation.
机译：胸脊髓横切后，发生截瘫综合征。先前的数据表明，急性给予5-HT2激动剂（奎巴嗪）可促进脊髓大鼠运动功能的恢复。然而，事实证明，通过渗透泵连续1个月的硬膜下灌流更为有效。本研究旨在调查5-HT1A受体可能参与这种恢复。在每天接受1个月剂量的5-HT1A激动剂8-OHDPAT的脊髓动物中分析运动表现和运动参数。将结果与在相同条件下接受安慰剂或喹嗪的脊髓大鼠中获得的结果进行比较。使用每日注射而不是将任一受体激动剂连续灌输给脊柱动物，可以表征药理刺激5-HT1A和5-HT2受体对运动功能恢复的短期和长期后果。我们的数据表明，每天注射5-HT1A激动剂可对运动功能恢复产生长期累积的积极影响，这可以通过在“日间测试”注射之前观察到的步行参数的改善来评估。这可能涉及依赖于使用的过程，这取决于对与5-HT受体激活有关的运动的脊髓网络的慢性和/或重复刺激。注射后短暂观察到的运动参数的进一步改善表明5-HT1A和5-HT2受体激活对参与运动模式生成的脊髓神经元具有更直接的作用。

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