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首页> 外文期刊>The European Journal of Neuroscience >The mid-ventrolateral prefrontal cortex: insights into its role in memory retrieval.
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The mid-ventrolateral prefrontal cortex: insights into its role in memory retrieval.

机译：腹侧前额叶中部皮层：洞察其在记忆恢复中的作用。

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摘要

Although it is widely known that the prefrontal cortex plays a role in memory, the specific contribution of particular prefrontal regions in mnemonic functions remains controversial. The present investigation examined whether the mid-ventrolateral prefrontal cortex is selectively involved in active memory retrieval in situations in which mnemonic traces are embedded in ambiguous relations and automatic recollection cannot lead to successful retrieval. Thirteen subjects participated in this event-related functional magnetic resonance imaging experiment. Throughout the scanning session, trials belonging to an experimental and a control condition were administered in a pseudorandom fashion. During the encoding phase of any particular trial, subjects were presented with a stimulus-complex that was a combination of a face and a spatial location on the screen. In the experimental active retrieval condition, a question cue following the encoding phase instructed the subjects to retrieve selectively one of thetwo aspects of the encoded stimulus-complex, i.e. the face or the location. In the control condition, the question cue that followed the encoding phase instructed the subjects simply to recall the initially presented stimulus-complex, so as to be able to make a decision during the test phase based on simple stimulus familiarity. The comparison of the signal obtained during the retrieval phase of these two conditions yielded an increase in activity selective to the right mid-ventrolateral prefrontal region. These results therefore establish a specific link between the mid-ventrolateral prefrontal cortex and active retrieval mechanisms.
机译：尽管众所周知，前额叶皮层在记忆中起一定作用，但是特定前额叶区域在记忆功能中的具体作用仍然存在争议。本研究调查了在助记符痕迹嵌入歧义关系并且自动记忆不能成功进行检索的情况下，中前外侧前额叶皮层是否选择性参与主动记忆检索。 13名受试者参加了该事件相关的功能磁共振成像实验。在整个扫描过程中，属于实验和对照条件的试验均以伪随机方式进行。在任何特定试验的编码阶段，都会向受试对象呈现一种刺激复合体，该复合体是面部和屏幕上空间位置的组合。在实验性主动检索条件下，编码阶段之后的问题提示指示受试者选择性地检索编码后的刺激复合体的两个方面之一，即面部或位置。在控制条件下，编码阶段之后的问题提示仅指示受试者回忆起初出现的刺激复合体，以便能够在测试阶段基于简单的刺激熟悉性做出决定。在这两个条件的恢复阶段所获得的信号的比较，导致对右中腹外侧前额叶区域选择性活动的增加。因此，这些结果在腹侧前额叶中叶皮层和活动性修复机制之间建立了特定的联系。

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