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首页> 外文期刊>The European Journal of Neuroscience >Dissociation between mesocortical dopamine release and fear-related behaviours in two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions.
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Dissociation between mesocortical dopamine release and fear-related behaviours in two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions.

机译：在两种从心理上选择的大鼠品系中，中脑皮层多巴胺释放与恐惧相关行为之间的解离在对厌恶状况的应对策略方面有所不同。

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The mesocortical and mesolimbic dopaminergic (DAergic) pathways are activated by either aversive or rewarding stimuli. The functional tone of these DAergic neurons also increases during the execution of cognitive tasks. The present study was designed to examine the relationship between mesocortical and mesolimbic DAergic function and the expression of fear-related behaviours as compared with attention- and cognition-related mechanisms (e.g. coping strategies), in response to aversive conditions. To this aim, we used two psychogenetically selected rat lines, Roman high-avoidance (RHA/Verh) and Roman low-avoidance (RLA/Verh), which display drastically different emotion- and coping-related behaviours in response to stressors: RLA/Verh rats are 'reactive copers' and more fearful than RHA/Verh rats, which are 'proactive copers'. Brain dialysis experiments demonstrated that tail-pinch (TP) and the anxiogenic compounds pentylenetetrazol (PTZ) and ZK 93426 increased DA output in the medial prefrontal cortex (PFCX) of RHA/Verh but not RLA/Verh, rats. In contrast, in the shell compartment of the nucleus accumbens (NAC shell), TP caused a small increase in DA output only in RLA/Verh rats, whereas PTZ and ZK 93426 had no significant effect on either line. RHA/Verh rats displayed more robust and longer lasting coping activity and less frequent freezing and self-grooming episodes than did RLA/Verh rats after TP, PTZ or ZK 93426. This dissociation between fear-related behaviour and cortical DAergic activation argues against the view that the latter may be involved in the control of fear-like responses. We therefore propose that the activation of mesocortical DAergic projections by aversive stimuli underlies the cognitive mechanisms that are triggered in an attempt to gain control over the stressor.
机译：中性皮层和中脑边缘的多巴胺能（DAergic）途径被厌恶或奖励性刺激激活。在认知任务的执行过程中，这些DA能神经元的功能性语调也会增加。本研究旨在检查中性皮层和中脑边缘DA能功能与恐惧相关行为的表达之间的关系，并将其与注意力和认知相关的机制（例如应对策略）相比较，以应对厌恶状况。为了达到这个目的，我们使用了两种从心理上选择的大鼠系：罗马高回避（RHA / Verh）和罗马低回避（RLA / Verh），它们在应对压力时表现出与情感和应对有关的行为截然不同：RLA / Verh大鼠是“反应性铜”，比RHA / Verh大鼠是“主动性铜”更可怕。脑透析实验表明，RHA / Verh大鼠的前额叶内侧皮层（PFCX）中的尾巴捏捏（TP）和焦虑化合物戊四氮（PTZ）和ZK 93426增加了DA的输出，而RLA / Verh则没有。相反，在伏伏核的壳区（NAC壳）中，TP仅在RLA / Verh大鼠中引起DA输出的少量增加，而PTZ和ZK 93426对这两个系均没有显着影响。与TP，PTZ或ZK 93426后的RLA / Verh大鼠相比，RHA / Verh大鼠表现出更强健和持久的应对活动，并且不经常出现冰冻和自我修饰事件。这种恐惧相关行为与皮层DA能量激活之间的这种联系反驳了这一观点。后者可能参与控制类似恐惧的反应。因此，我们建议通过厌恶性刺激激活中皮层DAergic投影奠定了认知机制的基础，该认知机制试图获得对应激源的控制。

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