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首页> 外文期刊>The European Journal of Neuroscience >Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task.
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Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task.

机译：在执行奖励偏好任务期间，灵长类动物背外侧和眶前额皮质的神经元活动。

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摘要

An important function of the prefrontal cortex (PFC) is the control of goal-directed behaviour. This requires information as to whether actions were successful in obtaining desired outcomes such as rewards. While lesion studies implicate a particular PFC region, the orbitofrontal cortex (OFC), in reward processing, neurons encoding reward have been reported in both the OFC and the dorsolateral prefrontal cortex (DLPFC). To compare and contrast their roles, we recorded simultaneously from both areas while two rhesus monkeys (Macaca mulatta) performed a reward preference task. The monkeys had to choose between pictures associated with different amounts of a juice reward. Neuronal activity in both areas reflected the reward amount. However, neurons in the DLPFC encoded both the reward amount and the monkeys' forthcoming response, while neurons in the OFC more often encoded the reward amount alone. Further, reward selectivity arose more rapidly in the OFC than the DLPFC. These results are consistent with reward information entering the PFC via the OFC, where it is passed to the DLPFC and used to control behaviour.
机译：前额叶皮层（PFC）的重要功能是控制目标定向行为。这就需要有关行动是否成功获得期望的结果（如奖励）的信息。虽然病变研究牵涉到特定的PFC区域，但在奖励处理中眶额皮质（OFC）中，在OFC和背外侧前额叶皮质（DLPFC）中都报告了编码奖励的神经元。为了比较和对比它们的作用，我们在两个地区同时记录了两只恒河猴（猕猴）执行奖励偏好任务。猴子必须在与不同数量的果汁奖励相关的图片之间进行选择。两个区域的神经元活动都反映了奖励金额。但是，DLPFC中的神经元编码了奖励金额和猴子即将发生的反应，而OFC中的神经元则更经常单独编码了奖励金额。此外，OFC中奖励选择性的出现比DLPFC更快。这些结果与通过OFC进入PFC的奖励信息相一致，然后将奖励信息传递给DLPFC并用于控制行为。

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