...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Influence of regular voluntary exercise on spontaneous and social stress-affected sleep in mice.
【24h】

Influence of regular voluntary exercise on spontaneous and social stress-affected sleep in mice.

机译：定期自愿运动对小鼠自发和社会应激影响的睡眠的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To investigate the impact of regular physical exercise on sleep, we assessed sleep-wake behaviour in male C57BL/6N mice with and without long-term access (i.e. 4 weeks) to a running wheel. We studied sleep-wake behaviour during undisturbed conditions as well as after social stress. The exercising mice ran approximately 4 km/day, which affected their physical constitution, their spontaneous sleep-wake pattern and their endocrine and sleep responses to stress. When compared with the control mice, exercising animals had more muscle substance, less body fat and heavier adrenal glands. At baseline, exercising mice showed fewer, but longer-lasting, sleep episodes (indicating improved sleep consolidation) and less rapid-eye-movement sleep. In both control and exercising mice, mild social stress (elicited by a 15-min social conflict) evoked elevated plasma levels of adrenocorticotrophic hormone and corticosterone, an increase in non-rapid-eye-movement sleep, an enhancement of low-frequency activity in the electroencephalogram within non-rapid-eye-movement sleep (indicating increased sleep intensity) and a decrease in wakefulness. However, as compared with the control animals, exercising mice responded to social stress with higher corticosterone levels, but not adrenocorticotrophic hormone levels, suggesting an increased sensitivity of their adrenal glands to adrenocorticotrophic hormone. Moreover, in control mice, social stress increased rapid-eye-movement sleep in parallel to non-rapid-eye-movement sleep, whereas this stressor selectively decreased rapid-eye-movement sleep in exercising animals. Corticosterone is known to decrease rapid-eye-movement sleep. Therefore, changes in the regulation of the hypothalamic-pituitary-adrenocortical axis as a result of the long-term exercise may contribute to the observed differences in spontaneous and social stress-affected sleep. In conclusion, regular exercise appears to increase sleep quality and reverses the effects of mild social stress on rapid-eye-movement sleep.
机译：为了研究常规体育锻炼对睡眠的影响，我们评估了有和没有长期接触（即4周）跑步轮的雄性C57BL / 6N小鼠的睡眠-觉醒行为。我们研究了在不受干扰的情况下以及社交压力后的睡眠-觉醒行为。运动的老鼠每天跑大约4公里，这影响了它们的身体构造，自发的睡眠-觉醒模式以及内分泌和睡眠对压力的反应。与对照组小鼠相比，运动中的动物具有更多的肌肉物质，更少的体脂和更重的肾上腺。在基线时，运动小鼠表现出较少但持续时间更长的睡眠发作（表明改善了睡眠巩固）和较少的快速眼动睡眠。在对照组和运动组小鼠中，轻度的社会压力（由15分钟的社会冲突引起）引起血浆肾上腺皮质营养激素和皮质酮水平升高，增加了非快速眼动睡眠，增强了低频活动。非快速眼动睡眠中的脑电图（表明睡眠强度增加）和清醒性降低。但是，与对照组动物相比，运动小鼠对社交压力的反应皮质酮水平更高，而肾上腺皮质营养激素水平却没有升高，表明它们的肾上腺对肾上腺皮质营养激素的敏感性增加。此外，在对照组小鼠中，社交压力增加了快速眼动睡眠的速度，而非快速眼动睡眠则增加了压力，而这种压力源选择性地降低了运动动物的快速眼动睡眠。已知皮质酮会减少快速眼动睡眠。因此，长期运动导致下丘脑-垂体-肾上腺皮质轴调节的变化可能导致观察到的自发性和社会性应激影响的睡眠差异。总之，经常运动似乎可以提高睡眠质量，并逆转轻度社交压力对快速动眼睡眠的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号