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首页> 外文期刊>The European Journal of Neuroscience >Actions of neuropeptide Y and growth hormone secretagogues in the arcuate nucleus and ventromedial hypothalamic nucleus.
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Actions of neuropeptide Y and growth hormone secretagogues in the arcuate nucleus and ventromedial hypothalamic nucleus.

机译：神经肽Y和生长激素促分泌素在弓形核和腹膜下丘脑核中的作用。

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摘要

Systemic or central administration of growth-hormone secretagogues (GHS) induces dense Fos expression in the arcuate nucleus but little or no Fos expression in the ventromedial hypothalamic nucleus, although both sites show intense expression of mRNA for the GHS receptor. Here, we recorded the electrical activity of single neurons from the arcuate nucleus and from the ventromedial hypothalamic nucleus in a rat hypothalamic slice preparation, and compared responses of these two populations to GHS. At both sites, the predominant neuronal response to GHS was a long-lasting excitation, indicating that GHS receptors at both sites are functional and similarly coupled to electrical excitation. We also tested neurons at both sites for their responses to neuropeptide Y and to somatostatin; at both sites the predominant response to each of these peptides was inhibitory. The arcuate cells that are activated by GHS include neuropeptide Y cells and growth hormone-releasing hormone cells. It seems possible that neuropeptide Y released in the ventromedial hypothalamus from the terminals of arcuate neurons counteracts the activation of ventromedial hypothalamic neurons by GHS in vivo, or that somatostatin released following liberation of growth hormone may do so.
机译：全身或集中施用生长激素促分泌素（GHS）会在弓形核中诱导密集的Fos表达，但在腹侧下丘脑核中诱导Fos的表达很少或没有，尽管这两个位点均显示了GHS受体的mRNA大量表达。在这里，我们记录了大鼠下丘脑切片制备中弓状核和腹侧下丘脑核中单个神经元的电活动，并比较了这两个种群对GHS的反应。在这两个部位，对GHS的主要神经元反应是持久的兴奋，表明在两个部位的GHS受体均具有功能，并且与电激发相似。我们还测试了两个部位的神经元对神经肽Y和生长抑素的反应。在两个位点上，对这些肽中的每一个的主要反应都是抑制性的。由GHS激活的弓形细胞包括神经肽Y细胞和生长激素释放激素细胞。从弓形神经元的末端在腹膜下丘脑中释放的神经肽Y似乎有可能抵消GHS在体内对腹膜下丘脑神经元的激活，或者生长激素释放后释放的生长抑素也可能这样做。

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