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首页> 外文期刊>The European Journal of Neuroscience >Hyperexcitability of intact neurons underlies acute development of trauma-related electrographic seizures in cats in vivo.
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Hyperexcitability of intact neurons underlies acute development of trauma-related electrographic seizures in cats in vivo.

机译：完整的神经元的过度兴奋性是猫体内与创伤相关的电图发作的急性发展的基础。

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摘要

Cortical trauma can lead to development of electrographic paroxysmal activities. Current views of trauma-induced epileptogenesis suggest that chronic neuronal hyperexcitability and extensive morphological reorganization of the traumatized cortex are required for the generation of electrographic seizures. However, the mechanisms responsible for the initiation of electrographic seizures shortly after cortical injury are poorly understood. Here we show that, in the experimental model of partially deafferented (undercut) cortex, an increase in intrinsic and synaptic excitability of neurons in areas adjacent to the undercut cortex is sufficient for the generation of electrographic paroxysmal activity within few hours after partial cortical deafferentation. Locally increased and spatially restricted neuronal excitability arose from the increased incidence of intrinsically bursting neurons, enhanced intrinsic and synaptic neuronal responsiveness, and slight disinhibition. These mechanisms only operate in neurons located in the vicinity of partially deafferented sites because, after the cortical injury, partially deafferented neurons are mostly silent and hypoexcitable. Our results suggest that trauma-induced electrographic seizures first arise in cortical fields that are closest to the site of injury and such seizures do not require long-term neuronal reorganization.
机译：皮质外伤可导致发作性电图发作。当前关于创伤诱发的癫痫发生的观点表明，产生电描记性癫痫发作需要慢性神经元过度兴奋和受创伤皮层的广泛形态重组。然而，对皮层损伤后不久引起电图发作的机制了解甚少。在这里，我们显示，在部分脱除咖啡因（底切）皮层的实验模型中，在部分脱除皮质的去皮后数小时之内，与底切皮质相邻的区域中神经元内在和突触兴奋性的增加足以产生电子阵发性活动。内在爆发性神经元的发生率增加，内在和突触神经元反应性增强以及轻微的抑制作用引起了局部增加和空间受限的神经元兴奋性。这些机制仅在位于部分脱除咖啡因的部位附近的神经元中起作用，因为在皮层损伤后，部分脱除脱咖啡因的神经元大多是沉默且兴奋性较低的。我们的结果表明，由创伤引起的电图癫痫发作首先出现在最靠近损伤部位的皮层区域，这种癫痫发作不需要长期的神经元重组。

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