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首页> 外文期刊>The European Journal of Neuroscience >SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats.
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SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats.

机译：SR141716A会降低海洛因的增强特性，但不会降低海洛因诱导的伏隔核多巴胺中枢的增加。

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摘要

The present experiments tested the hypothesis that the selective CB1 receptor antagonist SR141716A alters heroin self-administration by attenuating heroin-induced increases in nucleus accumbens dopamine levels. SR141716A pretreatment dose-dependently (0.3-3 mg/kg, i.p.) reduced operant heroin self-administration by male Wistar rats under a fixed ratio schedule of reinforcement, and significantly lowered the breaking point of responding for heroin under a progressive ratio schedule of reinforcement. These observations are consistent with recent reports that CB1 receptor inactivation reduces the rewarding properties of opiates. Operant responding for water reinforcement by water-restricted rats was unaltered by these SR141716A doses. Microdialysis tests revealed that heroin self-administration significantly increases interstitial dopamine levels in the nucleus accumbens shell of vehicle-pretreated control rats. However, whereas SR141716A pretreatment dose-dependently reduced heroin self-administration, it did not alter the heroin-associated increase in nucleus accumbens dopamine. These findings suggest that the CB1 antagonist-induced attenuation of heroin reward does not involve dopaminergic mechanisms in the nucleus accumbens shell.
机译：本实验测试了以下假设：选择性CB1受体拮抗剂SR141716A通过减弱海洛因诱导的伏隔核多巴胺水平的增加来改变海洛因的自我给药。 SR141716A预处理以剂量依赖性（0.3-3 mg / kg，ip）减少雄性Wistar大鼠在固定比例的增强方案下的操作性海洛因自我给药，并显着降低逐步增强比例的海洛因反应的断裂点。这些观察结果与最近的报道一致，即CB1受体失活会降低鸦片的有益特性。这些SR141716A剂量未改变禁水大鼠对补水的反应。微透析测试显示，海洛因的自我给药可显着增加媒介物预处理对照组大鼠伏隔核壳中的间质多巴胺水平。但是，尽管SR141716A预处理可剂量依赖性地减少海洛因的自我给药，但它并不能改变伏伏核多巴胺中与海洛因有关的增加。这些发现表明，CB1拮抗剂诱导的海洛因奖赏减弱不涉及伏伏核壳中的多巴胺能机制。

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