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首页> 外文期刊>The European Journal of Neuroscience >Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activity.
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Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activity.

机译：在性活动过程中，雄性大鼠脑室旁核中的细胞外多巴胺增加。

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摘要

Dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were measured in the dialysate obtained with vertical microdialysis probes implanted into the paraventricular nucleus of the hypothalamus of sexually potent male rats. Animals showed noncontact erections when put in the presence of, and copulated with a receptive (ovarietomized oestrogen and progesterone primed) female rat. Dopamine and DOPAC concentrations in the paraventricular dialysate increased 140% and 19%, respectively, above baseline values during exposure to the receptive female and 280% and 31%, respectively, during copulation. No changes in dopamine and DOPAC concentrations were detected in the paraventricular dialysate when sexually potent male rats were exposed to nonreceptive (ovariectomized not oestrogen plus progesterone primed) female rats. These results confirm the involvement of the paraventricular nucleus in control of erectile function and copulatory behaviour and show for the first time that dopamine neurotransmission is increased in this hypothalamic nucleus when erection occurs in physiological contexts.
机译：多巴胺和3,4-二羟基苯乙酸（DOPAC）的浓度是通过将垂直微透析探针植入性功能强的雄性大鼠下丘脑室旁核中获得的透析液中测得的。动物在有雌性大鼠（卵巢切除的雌激素和孕激素引发的）的存在下并与之交配时显示非接触性勃起。脑室透析液中多巴胺和DOPAC的浓度分别比接受雌性药物的基线值分别高出基线值140％和19％，而在交配过程中分别升高280％和31％。当性能力强的雄性大鼠暴露于非接受性（卵巢切除的非雌激素加孕激素引发的）雌性大鼠中时，在室旁透析液中未检测到多巴胺和DOPAC浓度的变化。这些结果证实了室旁核参与勃起功能和交配行为的控制，并且首次表明当在生理环境中勃起时，该下丘脑核中多巴胺神经传递增加。

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