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首页> 外文期刊>The European Journal of Neuroscience >Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats.
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Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats.

机译：低剂量可卡因自我给药会暂时增加，但高剂量可卡因会持续降低大鼠的大脑奖励功能。

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This study investigated the effects of self-administered cocaine on brain reward function, measured by intracranial self-stimulation (ICSS) reward thresholds in rats. Self-administration of 10 and 20 cocaine injections (0.25 mg per injection, equivalent to 4.94 +/- 0.23 and 9.88 +/- 0.46 mg/kg, self-administered over 40 +/- 6.9 and 99 +/- 11.9 min, respectively) lowered reward thresholds 15 min later, indicating a facilitation of rewarding ICSS, but had no effect at 2, 24 or 48 h after administration. Thus, self-administration of low cocaine doses did not cause persistent changes in brain reward function. Forty cocaine injections (19.64 +/- 0.94 mg/kg; self-administered over 185 +/- 10.9 min) also transiently lowered reward thresholds 15 min later, while significant threshold current elevations were observed at 2 and 24 h after administration, indicating persistent withdrawal-like reward deficits. Finally, 80 cocaine injections (39.53 +/- 1.84 mg/kg, self-administered over 376 +/- 19.9 min) significantly elevated thresholds 2 and 48 h after self-administration, but not at 24 h. Threshold currents also tended to be elevated 15 min after self-administration. Overall, these data suggest that as the amount of self-administered cocaine increases the motivation to consume further cocaine may be shifted, from obtaining the rewarding actions of cocaine to avoidance and alleviation of a cocaine-induced negative affective state.
机译：这项研究调查了可卡因对大鼠大脑奖励功能的影响，可卡因通过颅内自我刺激（ICSS）奖励阈值进行了测量。自我注射10和20次可卡因（每次注射0.25 mg，相当于4.94 +/- 0.23和9.88 +/- 0.46 mg / kg，分别在40 +/- 6.9和99 +/- 11.9分钟内自我给药）在15分钟后降低了奖励阈值，表明对奖励ICSS有所促进，但在给药后2、24或48 h无效。因此，低剂量可卡因的自我管理并未引起大脑奖励功能的持续改变。四十次可卡因注射液（19.64 +/- 0.94 mg / kg;在185 +/- 10.9分钟内自行给药）在15分钟后也短暂降低了奖励阈值，而在给药后2和24 h观察到明显的阈值电流升高，表明持续存在像提款一样的奖励赤字。最后，注射80次可卡因（39.53 +/- 1.84 mg / kg，在376 +/- 19.9分钟内自行给药）显着提高了自我给药后2和48 h的阈值，但在24 h时未升高。自我给药后15分钟，阈值电流也倾向于升高。总体而言，这些数据表明，随着自我管理可卡因数量的增加，消费更多可卡因的动机可能会从获得可卡因的奖励作用转向避免和减轻可卡因引起的负面情感状态。

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