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首页> 外文期刊>The European Journal of Neuroscience >Dopamine efflux in nucleus accumbens shell and core in response to appetitive classical conditioning.
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Dopamine efflux in nucleus accumbens shell and core in response to appetitive classical conditioning.

机译：多巴胺外排在伏隔核和壳核中，以适应经典的饮食条件。

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Dopamine transmission within the nucleus accumbens has been implicated in associative reinforcement learning. We investigated the effect of appetitive classical conditioning on dopamine efflux in the rat nucleus accumbens shell and core, as dopamine may be differentially activated by conditioned and unconditioned stimuli (CS, US) in these subregions. After implantation of microdialysis cannulae, rats were food restricted and trained for three consecutive days with three acquisition sessions per day. A 10-s noise (CS) was immediately followed by the delivery of two reward pellets (US) for the conditioned group (paired presentation), whereas conditioned stimuli and unconditioned stimuli were presented at random for the control group (unpaired presentation). On the fourth day, all rats were given a further CS + US session and two CS-alone sessions, and extracellular dopamine concentrations were measured (7.5 min/per sample). Behavioural measures (number of nose pokes, latency to nose poke after conditioned stimuli onset, locomotor activity) demonstrated that the paired groups showed a high level of conditioning. CS + US presentation increased dopamine equally in both shell and core of the paired and unpaired groups. CS alone presentation induced a conditioned dopamine release only in the paired groups. No significant difference was found between shell and core. Unlike previous conditioning paradigms involving either a more salient US (foot shock, addictive drug) or a more complex CS, the present paradigm, using normal reward pellets as US and a discrete auditory stimulus as CS, did not lead to differential responses in dopamine efflux in shell and core subregions of the nucleus accumbens.
机译：多巴胺在伏隔核内的传递与联想强化学习有关。我们调查了竞争性经典条件对伏隔核和核中多巴胺流出的影响，因为在这些子区域中，多巴胺可能受到条件和非条件刺激（CS，US）的激活。植入微透析套管后，限制大鼠进食，并连续三天训练，每天进行三次采集。 10 s噪音（CS）之后立即送达条件组（配对展示）的两个奖励颗粒（US），而对照组随机提供条件刺激和非条件刺激（未配对的展示）。在第四天，对所有大鼠进行进一步的CS + US治疗和两次CS-单独治疗，并测量细胞外多巴胺浓度（7.5min /每个样品）。行为指标（鼻kes的数量，条件刺激发作后鼻latency的潜伏期，运动能力）表明，配对组表现出较高的条件水平。 CS +美国的介绍对配对和未配对组的外壳和核心中的多巴胺均值增加。单独CS呈现仅在配对组中诱导条件性多巴胺释放。壳和核之间没有发现显着差异。与以前的涉及更显着的美国（足部休克，成瘾性药物）或更复杂的CS的调节范式不同，当前的范式使用正常的奖励药丸作为US并使用离散的听觉刺激作为CS，不会导致多巴胺流出的差异反应在伏伏核的壳和核心子区域中。

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