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首页> 外文期刊>The European Journal of Neuroscience >Galectin-1 in regenerating motoneurons.
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Galectin-1 in regenerating motoneurons.

机译：Galectin-1在再生运动神经元中。

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摘要

The exogenous application of recombinant galectin-1 has recently been shown to promote the rate of peripheral nerve regeneration. Endogenous neuronal galectin-1 expression has recently been demonstrated to increase after axotomy. Here we demonstrate a significant increase in the endogenous neuronal expression of galectin-1 mRNA in facial motoneurons after either a nerve resection or crush injury in mice. This increase in galectin-1 expression was due in part to the loss of target-derived factor(s) as indicated by both the return of galectin-1 expression to control levels following target re-innervation and the increase in galectin-1 expression after blockade of axonal transport by an interneuronal colchicine injection. Furthermore, interneuronal injections of glial-derived neurotrophic factor into the uninjured nerve also increased galectin-1 mRNA expression within facial motoneurons suggesting that positive signals may also be involved in the regulation of galectin-1 expression. Galectin-1 null mutantmice showed an attenuated rate of functional recovery of whisking movement after a facial nerve crush.
机译：重组半乳凝素-1的外源性应用近来已显示出可促进周围神经再生的速率。近来，内源性神经元galectin-1的表达已被证明在轴切术后增加。在这里，我们证明小鼠神经切除或挤压伤后面部运动神经元中半乳糖凝集素-1 mRNA的内源性神经元表达显着增加。 galectin-1表达的增加部分是由于靶标衍生因子的丧失所致，这既可以通过靶标重新神经支配后galectin-1表达恢复至对照水平，也可以通过靶点后galectin-1表达的增加来表明。神经内秋水仙碱注射液阻断轴突运输。此外，神经元间神经胶质源性神经营养因子注射到未受伤的神经也增加了面部运动神经元内galectin-1 mRNA的表达，这表明阳性信号也可能参与了galectin-1表达的调节。 Galectin-1无效突变小鼠的面部神经挤压后，其拂动运动的功能恢复率降低。

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