...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice.
【24h】

Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice.

机译：Delta9-四氢大麻酚可降低小鼠尼古丁戒断的身体和动机表现。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract The possible interactions between Delta9-tetrahydrocannabinol (Delta9-THC) and nicotine remain unclear in spite of the current association of cannabis and tobacco in humans. The aim of the present study was to explore the interactions between these two drugs of abuse by evaluating the consequences of Delta9-THC administration on the somatic manifestations and the aversive motivational state associated with nicotine withdrawal in mice. Acute Delta9-THC administration significantly decreased the incidence of several nicotine withdrawal signs precipitated by mecamylamine or naloxone, such as wet-dog-shakes, paw tremor and scratches. In both experimental conditions, the global withdrawal score was also significantly attenuated by acute Delta9-THC administration. This effect of Delta9-THC was not due to possible adaptive changes induced by chronic nicotine on CB(1) cannabinoid receptors, as the density and functional activity of these receptors were not modified by chronic nicotine administration in the different brain structures investigated. We also evaluated the consequences of Delta9-THC administration on c-Fos expression in several brain structures after chronic nicotine administration and withdrawal. c-Fos was decreased in the caudate putamen and the dentate gyrus after mecamylamine precipitated nicotine withdrawal. However, acute Delta9-THC administration did not modify c-Fos expression under these experimental conditions. Finally, Delta9-THC also reversed conditioned place aversion associated to naloxone precipitated nicotine withdrawal. Taken together, these results indicate that Delta9-THC administration attenuated somatic signs of nicotine withdrawal and this effect was not associated with compensatory changes on CB(1) cannabinoid receptors during chronic nicotine administration. In addition, Delta9-THC also ameliorated the aversive motivational consequences of nicotine withdrawal.
机译：摘要尽管目前大麻和烟草在人类中的关联，但仍不清楚Delta9-四氢大麻酚（Delta9-THC）与尼古丁之间的可能相互作用。本研究的目的是通过评估Delta9-THC给药对小鼠体细胞表现和与尼古丁戒断相关的厌恶动机状态的后果，探索这两种滥用药物之间的相互作用。急性Delta9-THC给药可显着降低由美卡敏或纳洛酮沉淀的几种尼古丁戒断症状的发生率，例如湿狗震动，爪震颤和擦伤。在两种实验条件下，急性Delta9-THC给药也显着降低了总体戒断评分。 Delta9-THC的这种作用不是由于慢性尼古丁对CB（1）大麻素受体可能引起的适应性变化，因为在研究的不同大脑结构中，这些受体的密度和功能活性并未因长期尼古丁给药而改变。在慢性尼古丁给药和戒断后，我们还评估了Delta9-THC给药对c-Fos表达在几个脑结构中的影响。美卡敏胺沉淀尼古丁戒断后，尾状壳和齿状回中的c-Fos降低。但是，在这些实验条件下，急性Delta9-THC给药不会改变c-Fos表达。最后，Delta9-THC还逆转了与纳洛酮沉淀的尼古丁戒断相关的条件性位置反感。两者合计，这些结果表明，Delta9-THC给药减弱了尼古丁戒断的体征，并且这种作用与慢性尼古丁给药期间对CB（1）大麻素受体的补偿性变化无关。此外，Delta9-THC还改善了尼古丁戒断的反感动机后果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号