...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >CREB deficient mice show inhibition and low activity in novel environments without changes in stress reactivity.
【24h】

CREB deficient mice show inhibition and low activity in novel environments without changes in stress reactivity.

机译：CREB缺陷小鼠在新的环境中显示出抑制作用和低活性，而应激反应性却没有变化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract The ability to respond to unexpected or novel stimuli is critical for survival. Determining that a stimulus is indeed novel requires memory to ascertain its lack of familiarity. As the long-term synaptic changes involved in memory formation require the cAMP response element binding protein (CREB), we examined the extent to which CREB is involved in responses to novel environments. These environments typically trigger an endocrine stress response. Thus, we measured behavioural and stress hormone responses to three novel and one familiar environment in mice with a targeted disruption of the alpha and delta isoforms of the CREB gene (CREB(alphadelta-) deficient mice). We found CREB(alphadelta-) deficient mice to be less active and more inhibited in the elevated plus maze, open field, and light/dark box, without showing differences in anxiety-like behaviour. This inhibition is unique to novel environments because these mice display a normal phenotype in the home cage, a familiar environment. Although CREB(alphadelta-) deficient mice exhibit altered behaviour in novel environments, they show normal reactivity to mild and moderate stress as both basal and stress levels of corticosterone are similar to those of wild-type controls. This is the first report of CREB(alphadelta-) deficient mice to: (i) show altered behaviour, not related to learning and memory-associated behaviours, upon initial exposure to environments and (ii) serve as an animal model that can dissociate locomotor activity from anxiety-like behaviour in novel environments.
机译：摘要应对意外或新颖刺激的能力对于生存至关重要。确定刺激确实是新颖的，需要记忆来确定其缺乏熟悉性。由于参与记忆形成的长期突触变化需要cAMP反应元件结合蛋白（CREB），因此我们研究了CREB参与对新型环境的反应的程度。这些环境通常会触发内分泌应激反应。因此，我们在有针对性地破坏CREB基因的alpha和delta亚型的小鼠（CREB（alphadelta-）缺陷小鼠）中测量了对三种新颖和一种熟悉环境的行为和应激激素反应。我们发现CREB（alphadelta-）缺陷小鼠在高架迷宫，开阔地带和明/暗盒中活动性较低，并受到更多抑制，而没有表现出类似焦虑的行为。这种抑制作用是新型环境所特有的，因为这些小鼠在家庭笼子（熟悉的环境）中显示正常的表型。尽管CREB（alphadelta-）缺陷小鼠在新型环境中表现出改变的行为，但它们显示出对轻度和中度应激的正常反应性，因为皮质酮的基础和应激水平均与野生型对照相似。这是CREB（alphadelta-）缺陷小鼠的首次报道：（i）初次暴露于环境后，其行为改变，与学习和记忆相关的行为无关，并且（ii）成为可分离运动的动物模型新型环境中的类似焦虑行为引起的活动。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号