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首页> 外文期刊>The European Journal of Neuroscience >Time course for the reappearance of vibrissal motor representation following botulinum toxin injection into the vibrissal pad of the adult rat.
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Time course for the reappearance of vibrissal motor representation following botulinum toxin injection into the vibrissal pad of the adult rat.

机译：将肉毒杆菌毒素注射到成年大鼠的滑膜垫中后，滑膜运动表现再次出现的时程。

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Abstract The present study investigates the time course and pattern of movement representation recovery in the motor cortex during the recovery after a peripheral paralysis. To this end a transitory flaccid paralysis of the vibrissae muscle was induced in adult rats that underwent two unilateral injections of 8 U of botulinum toxin (BTX) into a vibrissal pad, at a duration of 12 days from one another. The compound muscle action potential (MAP) of the vibrissae muscle began to reappear 4 weeks after the first BTX injection. Intracortical microstimulation (ICMS) was used to map rat motor cortices 4, 5, 6, 7 and 8 weeks after the first BTX injection. Findings demonstrated that: (i) contralateral vibrissae movement reappears in the medial part of its normal cortical territory when the MAP is almost 10% of the control value; in the remaining part, ICMS elicits eye, ipsilateral vibrissae, neck and forelimb movements; (ii) the contralateral vibrissae movement reappears in sites where ipsilateral vibrissae and/or neck movement are co-represented; (iii) as MAP recovers, the vibrissae representation expands until it recovers the 90.8% of its territory after 7 weeks, when the MAP was almost 43.4% of the control value; (iv) from 4 to 7 weeks, the ICMS-evoked contralateral vibrissae movement shows a significantly higher electrical threshold vs. the control group; (v) recovery of the baseline excitability uniformly involves the vibrissae representation 1 week later, after its cortical territory has recovered 93.1% of the control value and the MAP has returned to 78.8% of the baseline value.
机译：摘要本研究探讨运动性皮层运动表征恢复在周围麻痹后恢复过程中的时程和模式。为此，在成年大鼠中诱发了纤毛的暂时性松弛性麻痹，成年大鼠经过两次单侧注射8 U的肉毒杆菌毒素（BTX）到触觉垫中，彼此间隔12天。首次注射BTX后4周，触须肌的复合肌肉动作电位（MAP）开始重新出现。皮层内微刺激（ICMS）用于在第一次BTX注射后第4、5、6、7和8周绘制大鼠运动皮质。研究结果表明：（i）当MAP接近对照值的10％时，对侧触须运动重新出现在其正常皮质区域的中间部分;在其余部分，ICMS引起眼睛，同侧触须，颈部和前肢运动; （ii）在同时代表同侧触须和/或颈部运动的部位，再次出现对侧触须运动; （iii）随着MAP的恢复，触须的数量不断扩大，直到7周后它恢复了其控制面积的43.4％时恢复了其90.8％的领土; （iv）从4周到7周，与对照组相比，ICMS诱发的对侧触毛运动显示出明显的电阈值; （v）基线兴奋性的恢复在1周后均匀地包含触须表现，这是因为其皮层区已恢复到控制值的93.1％，而MAP已恢复到基线值的78.8％。

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