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首页> 外文期刊>The European Journal of Neuroscience >Postnatal emergence of mature release properties in terminals of rat fast- and slow-twitch muscles.
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Postnatal emergence of mature release properties in terminals of rat fast- and slow-twitch muscles.

机译：产后大鼠快和慢肌抽搐肌肉末端成熟释放特性的出现。

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Abstract Motor nerve terminals in adult mammalian slow-twitch muscles have lower levels of spontaneous and evoked neurotransmitter release than terminals in fast-twitch muscles. These reflect adaptive differences, allowing terminals in slow (postural) muscles to sustain release during the prolonged firing trains experienced in vivo. Here we ask whether these differences in terminal release properties in Sprague-Dawley rat extensor digitorum longus (EDL, fast) and soleus (slow) muscles reflect their early cytodifferentiation in the embryo or whether they might be adaptations to their distinct mature activity patterns, which emerge around two weeks postnatally. We find that the mature pattern of differences in release arise through co-ordinated increases in presynaptically dependent release properties (quantal content, spontaneous release frequency and evoked potential amplitude), beginning at three weeks, which are particularly substantial in EDL. In contrast, other synaptic properties are either consistently greater in the same muscle throughout development (evoked potential kinetics, muscle fibre diameter) or display no systematic muscle type-dependent differences (terminal area, input resistance, spontaneous release amplitude). Thus, the emergence of adaptive differences in terminal release properties correlates with the differentiation of locomotor activity patterns in postnatal rat hindlimb muscles.
机译：摘要成年哺乳动物慢肌的运动神经末梢的自发性和诱发性神经递质释放水平低于快肌的末梢。这些反映了适应性差异，使缓慢（姿势）肌肉中的末端在体内经历的长时间射击训练中得以持续释放。在这里，我们问Sprague-Dawley大鼠趾长伸肌（EDL，快速）和比目鱼肌（慢）肌肉末端释放特性的这些差异是否反映了它们在胚胎中的早期细胞分化，或者它们是否可能适应了它们独特的成熟活动模式，产后两周左右出现。我们发现，释放差异的成熟模式是通过突触前依赖性释放特性（含量，自发释放频率和诱发电位振幅）的协同增加而产生的，从三周开始，这在EDL中尤为明显。相反，在整个发育过程中同一肌肉中的其他突触特性始终较高（诱发电位动力学，肌肉纤维直径），或者没有系统性的依赖于肌肉类型的差异（末端面积，输入阻力，自发释放幅度）。因此，终末释放特性的适应性差异的出现与产后大鼠后肢肌肉运动活动模式的分化相关。

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