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首页> 外文期刊>The European Journal of Neuroscience >Environmental enrichment enhances auditory takeover of the occipital cortex in anophthalmic mice.
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Environmental enrichment enhances auditory takeover of the occipital cortex in anophthalmic mice.

机译：环境富集增强了眼盲小鼠的枕叶皮听觉接管。

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Abstract Enrichment of the environment is an effective means of enhancing neuronal development and plasticity but its effect on the cross-modal compensation resulting from sensory deprivation has never been investigated. The present study used c-Fos immunohistochemistry and dextran-biotin neuronal tracing to examine the reorganization of sensory modalities in the brain of anophthalmic mutant mice (ZRDCT/An) raised in either enriched or standard environments. Auditory stimulation was found to elicit strong neuronal activation in thalamic and cortical structures that are normally visual. An important finding was that the latter auditory-evoked cortical activity was considerably enhanced in blind mice raised in the enriched environment. The axonal tracing study demonstrated auditory inputs from the inferior colliculus to the visual thalamus. This animal model will be useful for understanding neuronal mechanisms underlying some cross-modal sensory phenomena observed in blind or deaf humans.
机译：摘要富集环境是增强神经元发育和可塑性的有效手段，但对由感觉剥夺引起的交叉模式补偿的影响尚未得到研究。本研究使用c-Fos免疫组织化学和右旋糖酐-生物素神经元示踪，以检查在富营养或标准环境中饲养的脱眼突变小鼠（ZRDCT / An）大脑中的感觉模态的重组。发现听觉刺激在通常是视觉的丘脑和皮质结构中引起强烈的神经元活化。一个重要发现是，在丰富的环境中饲养的盲鼠中，后者的听觉诱发的皮层活动大大增强了。轴突追踪研究显示了从下丘脑到视觉丘脑的听觉输入。这种动物模型将有助于理解在盲人或聋人中观察到的一些交叉模式感觉现象背后的神经元机制。

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