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首页> 外文期刊>The European Journal of Neuroscience >Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible.
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Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible.

机译：在急性和慢性应激后，大鼠齿状回的增殖抑制和凋亡变化是可逆的。

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Acute stress suppresses new cell birth in the hippocampus in several species. Relatively little is known, however, on how chronic stress affects the turnover, i.e. proliferation and apoptosis, of the rat dentate gyrus (DG) cells, and whether the stress effects are lasting. We investigated how 3 weeks of chronic unpredictable stress would influence the structural dynamic plasticity of the rat DG, and studied newborn cell proliferation, survival, apoptosis, volume and cell number in 10-week-old animals. To study lasting effects, another group of animals was allowed to recover for 3 weeks. Based on two independent parameters, bromodeoxyuridine (BrdU) and Ki-67 immunocytochemistry, our results show that both chronic and acute stress decrease new cell proliferation rate. The reduced proliferation after acute stress normalized within 24 h. Interestingly, chronically stressed animals showed recovery after 3 weeks, albeit with still fewer proliferating cells than controls. Apoptosis, by contrast, increased after acute but decreased after chronic stress. These results demonstrate that, although chronic stress suppresses proliferation and apoptosis, 3 weeks of recovery again normalized most of these alterations. This may have important implications for our understanding of the reversibility of stress-related hippocampal volume changes, such as occur, for example, in depression.
机译：急性应激会抑制几种物种的海马新细胞出生。然而，关于慢性应激如何影响大鼠齿状回（DG）细胞的更新（即，增殖和凋亡）的知之甚少，以及这种应激作用是否持久。我们研究了3周的慢性不可预知的应激如何影响大鼠DG的结构动态可塑性，并研究了10周龄动物的新生细胞增殖，存活，凋亡，体积和细胞数量。为了研究持久的作用，允许另一组动物恢复3周。基于两个独立参数，溴脱氧尿苷（BrdU）和Ki-67免疫细胞化学，我们的结果表明，慢性和急性应激均会降低新细胞的增殖速率。急性应激后减少的增殖在24小时内恢复正常。有趣的是，慢性应激动物在3周后恢复，尽管其增殖细胞仍比对照组少。相反，凋亡在急性后增加，而在慢性应激后减少。这些结果表明，尽管慢性应激抑制了增殖和凋亡，但3周的恢复又使大多数这些改变恢复了正常。这可能对我们理解与压力相关的海马体积变化（例如在抑郁症中发生）的可逆性具有重要意义。

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