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首页> 外文期刊>The European Journal of Neuroscience >NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala.
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NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala.

机译：NMDA受体对于在外侧杏仁核中获得条件恐惧和相关性峰值发射至关重要，但不是表达所需。

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摘要

Abstract We examined the contribution of N-methyl-D-aspartate (NMDA) receptors (NMDARs) to the acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using single-unit recording techniques in behaving rats. We demonstrate that NMDARs are essential for the acquisition of both behavioral and neuronal correlates of conditional fear, but play a comparatively limited role in their expression. Administration of the competitive NMDAR antagonist +/--3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) prior to auditory fear conditioning completely abolished the acquisition of conditional freezing and conditional single-unit activity in the lateral amygdala (LA). In contrast, CPP given prior to extinction testing did not affect the expression of conditional single-unit activity in LA, despite producing deficits in conditional freezing. Administration of CPP also blocked the induction of long-term potentiation in the amygdala. Together, these data suggest that NMDARs are essential for the acquisition of conditioning-related plasticity in the amygdala, and that NMDARs are more critical for regulating synaptic plasticity and learning than routine synaptic transmission in the circuitry supporting fear conditioning.
机译：摘要：我们研究了行为大鼠中N-甲基-D-天门冬氨酸（NMDA）受体（NMDARs）对杏仁状可塑性和巴甫洛夫恐惧条件的获取和表达的贡献。我们证明，NMDAR对获得条件恐惧的行为和神经相关都至关重要，但在其表达中起相对有限的作用。在听觉恐惧调理之前，竞争性NMDAR拮抗剂+ /-3-（2-羧基哌嗪-4-基）丙基-1-膦酸（CPP）的使用完全取消了条件性冷冻和条件性单单位活性的获得外侧杏仁核（LA）。相比之下，在消光试验之前给予的CPP不会影响LA中条件性单单位活性的表达，尽管条件性冻结会产生缺陷。 CPP的给药也阻断了杏仁核中长时程增强的诱导。总之，这些数据表明，NMDAR对于获得杏仁核中与条件相关的可塑性至关重要，并且与支持恐惧条件调节的常规突触传递相比，NMDAR对于调节突触可塑性和学习更为关键。

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