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首页> 外文期刊>The European Journal of Neuroscience >Nitric oxide released by gastric mechanoreceptors modulates nicotinic activation of coeliac plexus neurons in the rabbit.
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Nitric oxide released by gastric mechanoreceptors modulates nicotinic activation of coeliac plexus neurons in the rabbit.

机译：胃机械感受器释放的一氧化氮调节兔腹腔神经丛神经元的烟碱样活化。

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摘要

The effects on the nicotinic activation of the coeliac plexus neurons of nitric oxide (NO) released within the coeliac plexus by gastric mechanoreceptors, in particular during gastroduodenal inhibitory reflex, were assessed. This study was performed in the rabbit on an in vitro preparation of the coeliac plexus connected to the stomach and the duodenum. The electrical activity of ganglionic neurons was recorded with intracellular recording techniques. Water-filled balloons were used for gastric distensions and recording of duodenal motility. When a 10-s train of pulses (20-40Hz) of supramaximal intensity was applied to the splanchnic nerves, gradual depression of nicotinic activation occurred. Gastric distension (50 mL, 7.5 min) modulated this depression phenomenon by inhibiting or facilitating the nicotinic activation. In the neurons impaled during the recording of duodenal motility, gastric distension triggered an inhibition of nicotinic activation concomitantly with a gastroduodenal inhibitory reflex organized by the coeliac plexus. If the gastric distensions were performed while the coeliac plexus was superfused by a NO scavenger, the nicotinic activation was unaffected and the gastroduodenal inhibitory reflex was abolished. Moreover, when the coeliac plexus was superfused with an inhibitor of nitric oxide synthase, gastric distensions were without effect on the nicotinic activation. These results demonstrate that NO released within the coeliac plexus by gastric mechanoreceptors, in particular during the gastroduodenal inhibitory reflex, modulates the central nicotinic activation of coeliac plexus neurons, so NO released within a prevertebral ganglion by gastric afferent fibres, in particular during the organization by this ganglion of a reflex regulating the gastrointestinal tract motility, also exerts a gating of the central inputs to the ganglionic neurons.
机译：评估了胃机械感受器对腹腔神经丛内释放的一氧化氮（NO）的腹腔神经丛神经元烟碱活化的影响，特别是在十二指肠抑制反射期间。这项研究是在兔子体外制备连接至胃和十二指肠的腹腔神经丛的过程中进行的。用细胞内记录技术记录神经节神经元的电活动。将充满水的气球用于胃扩张和记录十二指肠蠕动。当对内脏神经施加10s超最大强度的脉冲（20-40Hz）时，烟碱活化逐渐降低。胃胀（50 mL，7.5分钟）通过抑制或促进烟碱样活化来调节这种抑郁现象。在记录十二指肠运动过程中被刺穿的神经元中，胃胀气伴随着由腹腔神经丛组织的胃十二指肠抑制性反射触发了烟碱样激活的抑制。如果在腹腔神经丛被NO清除剂融合的同时进行了胃扩张，则烟碱样激活不会受到影响，而胃十二指肠抑制性反射也将被取消。此外，当腹腔神经丛与一氧化氮合酶抑制剂融合时，胃扩张对烟碱样激活没有影响。这些结果表明，胃机械感受器在腹腔神经丛内释放的NO，特别是在胃十二指肠抑制反射期间，可调节腹腔神经丛神经元的中枢烟碱活化，因此NO在胃前神经节内由胃传入纤维释放，特别是在组织的过程中。调节胃肠道运动的反射神经节，也对神经节神经元的中央输入施加门控。

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