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首页> 外文期刊>The European Journal of Neuroscience >Abnormal substance P release from the spinal cord following injury to primary sensory neurons.
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Abnormal substance P release from the spinal cord following injury to primary sensory neurons.

机译：初级感觉神经元受伤后，脊髓中异常P物质释放。

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摘要

The neuropeptide substance P (SP) modulates nociceptive transmission within the spinal cord. Normally, SP is uniquely contained in a subpopulation of small-calibre axons (Adelta- and C-fibres) within primary afferent nerve. However, it has been shown that after nerve transection, besides being downregulated in small axons, SP is expressed de novo in large myelinated Abeta-fibres. In this study we investigated whether, following peripheral nerve injury, SP was released de novo from the spinal cord after selective activation of Abeta-fibres. Spinal cords with dorsal roots attached were isolated in vitro from rats 2 weeks following distal sciatic axotomy or proximal spinal nerve lesion (SNL). The ipsilateral dorsal roots were electrically stimulated for two consecutive periods at low- or high-threshold fibre strength, spinal cord superfusates were collected and SP content was determined by radioimmunoassay. SNL, but not axotomized or control rat cords, released significant amounts of SP after selective activation of Abeta-fibres. Not only do these data support the idea that Abeta myelinated fibres contribute to neuropathic pain by releasing SP, they also illustrate the importance of the proximity of the lesion to the cell body.
机译：神经肽物质P（SP）调节脊髓内的伤害性传递。通常，SP独特地包含在初级传入神经内的小口径轴突（Adelta和C纤维）的子群中。然而，已经表明，神经横切后，除了在小轴突中被下调外，SP在大型有髓Abeta纤维中从头表达。在这项研究中，我们研究了在选择性激活Abeta纤维后，周围神经损伤后，SP是否从脊髓从头释放。在远端坐骨神经切断或近端脊髓神经病变（SNL）2周后，从大鼠体外分离附有背根的脊髓。在低或高阈值纤维强度下连续两个刺激同侧背根，收集脊髓超融合蛋白，并通过放射免疫测定法测定SP含量。在选择性激活Abeta纤维后，SNL却未切除轴索或对照大鼠脐带，释放了大量SP。这些数据不仅支持Abeta髓质纤维通过释放SP促进神经性疼痛的想法，而且还说明了病变与细胞体接近的重要性。

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