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首页> 外文期刊>The European Journal of Neuroscience >Olfactory transduction in ciliated receptor neurons of the Cabinza grunt, Isacia conceptionis (teleostei: haemulidae).
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Olfactory transduction in ciliated receptor neurons of the Cabinza grunt, Isacia conceptionis (teleostei: haemulidae).

机译：Cabinza咕unt声，伊萨奇亚（teleostei：haemulidae）的纤毛受体神经元的嗅觉转导。

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Abstract The ciliated receptor neurons of fish olfactory organs are thought to transduce amino acids through a cAMP-dependent transduction pathway, but direct physiological evidence for this hypothesis remains scarce and is confined to catfish and trout. We investigated olfactory transduction in a marine fish, the Cabinza grunt Isacia conceptionis (Perciformes, Teleostei). The olfactory epithelium was characterized using light and electron microscopy, and isolated ciliated receptor neurons were recorded with the perforated patch-clamp technique. Cells were stimulated with puffer pipettes containing amino acid odourants, IBMX plus forskolin or 8bromo-cAMP. All three stimuli triggered transient inward currents at a holding potential of -70 mV and responses with outward-rectifying current-voltage relationships. The characteristics of the transduction currents induced by each stimulus were similar across cells and indistinguishable within the same cell, supporting the hypothesis of a cAMP pathway mediatingtransduction of amino acids in ciliated olfactory receptor neurons.
机译：摘要人们认为鱼类嗅觉器官的纤毛受体神经元通过cAMP依赖的转导途径来转导氨基酸，但该假说的直接生理学证据仍然稀少，仅限于cat鱼和鳟鱼。我们调查了一种海洋鱼类，Cabinza grunt Isacia conceptionis（Perciformes，Teleostei）的嗅觉传导。使用光学和电子显微镜对嗅觉上皮进行表征，并使用穿孔膜片钳技术记录分离的纤毛受体神经元。用含有氨基酸气味剂，IBMX加福司可林或8bromo-cAMP的河豚吸管刺激细胞。所有这三个刺激均以-70 mV的保持电势触发了瞬态的内向电流，并具有向外整流的电流-电压关系。每个刺激物诱导的转导电流的特征在整个细胞之间相似，并且在同一细胞内无法区分，从而支持了cAMP途径介导纤毛嗅觉受体神经元中氨基酸转导的假设。

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