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首页> 外文期刊>The European Journal of Neuroscience >Long-term effects of striatal lesions on c-Fos immunoreactivity in the pedunculopontine nucleus.
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Long-term effects of striatal lesions on c-Fos immunoreactivity in the pedunculopontine nucleus.

机译：纹状体病变对pedunculopontine核中c-Fos免疫反应性的长期影响。

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The basal ganglia are a group of subcortical nuclei classically thought to be involved in the control of movement, and they have reciprocal connections with the cortex, thalamus and structures in the brainstem. Recent findings suggest that the basal ganglia interact with structures involved in the control of the sleep-waking cycle. The pedunculopontine tegmental nucleus (PPN) maintains a close relationship with the basal ganglia and is intimately involved in the regulation of wakefulness and REM sleep. This study evaluated changes in activity of PPN neurons following striatal kainic acid-induced lesions. Rats were injected in the anterodorsal striatum with either kainic acid or vehicle and allowed to recover for 7 or 30 days. The results showed an increase in the number of c-Fos+ cells in the PPN 30 days but not 7 days after the striatal lesion, when motor hyperactivity was no longer detected. In addition, we found a significant correlation between the ventricular brain ratio, as an indicator of lesionsize, and the number of c-Fos+ cells in the PPN. Furthermore, the spatial distribution of cell types suggested that most c-Fos+ cells in the PPN were not cholinergic. These results provide new insights into the functional relationship between the basal ganglia and the PPN and suggest that the striatum, through its indirect influence on the PPN, may contribute to the regulation of wakefulness and cortical activation.
机译：基底神经节是一组皮层下核，通常被认为与运动的控制有关，它们与大脑皮层，丘脑和脑干结构具有相互联系。最近的发现表明，基底神经节与参与觉醒周期控制的结构相互作用。足桥骨被盖核（PPN）与基底神经节保持密切关系，并密切参与清醒和REM睡眠的调节。这项研究评估了纹状石红酸诱导的损伤后PPN神经元活性的变化。用海藻酸或溶媒将大鼠注射到前纹状体中，使其恢复7天或30天。结果显示，纹状体损伤后30天而不是7天，PPN中c-Fos +细胞的数量增加了，此时不再检测到运动亢进。此外，我们发现室脑比例（作为病变程度的指标）与PPN中c-Fos +细胞的数量之间存在显着相关性。此外，细胞类型的空间分布表明PPN中大多数c-Fos +细胞不是胆碱能的。这些结果为基底神经节与PPN之间的功能关系提供了新的见解，并暗示纹状体通过其对PPN的间接影响，可能有助于调节觉醒和皮质激活。

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