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首页> 外文期刊>The European Journal of Neuroscience >Striatal contributions to working memory: a functional magnetic resonance imaging study in humans.
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Striatal contributions to working memory: a functional magnetic resonance imaging study in humans.

机译：纹状体对工作记忆的贡献：人体功能性磁共振成像研究。

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Although the role of the frontal cortex in executive performance has been widely accepted, issues regarding the contribution of subcortical structures to these functions remain unresolved. In this study, the neural circuitry underlying selective subcomponents of working memory was investigated using event-related functional magnetic resonance imaging (fMRI). Ten healthy volunteers performed a verbal memory task, which allowed different aspects of working memory function such as maintenance, retrieval and manipulation to be tested within the same general paradigm. During performance of this task as a whole, fMRI revealed increases in signal intensity throughout the frontostriatal network. However, when signal intensity during the manipulation of information within working memory was compared to that during periods requiring only simple maintenance and retrieval, significant changes were observed only in the caudate nuclei, bilaterally. These results suggest an essential and specific role for the caudatenucleus in executive function, which may underlie the cognitive disturbances observed in frontostriatal neurodegenerative disorders such as Parkinson's disease.
机译：尽管额叶皮质在执行性能中的作用已被广泛接受，但有关皮质下结构对这些功能的贡献的问题仍未解决。在这项研究中，使用事件相关功能磁共振成像（fMRI）研究了工作记忆选择性子成分的神经回路。十名健康志愿者执行了一项口头记忆任务，该任务允许在相同的通用范式下测试工作记忆功能的不同方面，例如维护，检索和操纵。在整个任务执行过程中，fMRI显示整个前额窦网络的信号强度增加。但是，将工作记忆中的信息处理过程中的信号强度与仅需要简单维护和检索的期间的信号强度进行比较时，仅在双侧尾状核中观察到了显着变化。这些结果表明，尾状核在执行功能中起着至关重要的作用，这可能是在额叶神经退行性疾病（如帕金森氏病）中观察到的认知障碍的基础。

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