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首页> 外文期刊>The European Journal of Neuroscience >Isoflurane modulates glutamatergic and GABAergic neurotransmission in the amygdala.
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Isoflurane modulates glutamatergic and GABAergic neurotransmission in the amygdala.

机译：异氟烷调节杏仁核中的谷氨酸能和GABA能神经传递。

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Abstract Attempts have been made to attribute the particular features of general anaesthesia such as hypnosis, analgesia, amnesia and autonomic stability to certain brain regions. In the present study, we examined the effects of the commonplace volatile anaesthetic isoflurane on synaptic transmission in an in vitro slice preparation of the murine amygdala. Despite the established role of this limbic structure in the formation of aversive memories, conditioned fear and anxiety, as well as pain processing and regulation of sympathetic tone, the influence of volatile anaesthetics on synaptic signalling has not yet been investigated in this region of the brain. Evoked postsynaptic currents were monitored from principal neurons in the basolateral nucleus of the amygdala by means of patch-clamp recording. The mixed postsynaptic currents were mediated by non-NMDA, NMDA, GABA(A) and GABA(B) receptors. Isoflurane added to the perfusion medium reduced the strength of synaptic signalling following the activation of non-NMDA, NMDA, and GABA(B) receptors, whereas the GABA(A) receptor-mediated responses were enhanced. The overall reduction of neuronal excitability was also reflected in a reduction of field potential amplitudes. Isoflurane neither changed the membrane resting potential nor the input resistance of principal neurons in the amygdala. The present results may contribute to the understanding of how stress reactions and long-lasting neuroplastic processes are suppressed under general anaesthesia.
机译：摘要有人尝试将全身麻醉的特定特征（例如催眠，镇痛，健忘症和自主神经稳定性）归因于某些大脑区域。在本研究中，我们在鼠杏仁体的体外切片制备中检查了普通挥发性麻醉剂异氟烷对突触传递的影响。尽管该边缘结构在厌恶性记忆形成，条件性恐惧和焦虑以及疼痛处理和交感神经调节中发挥了确定的作用，但尚未在大脑的这一区域研究挥发性麻醉剂对突触信号传导的影响。 。通过膜片钳记录从杏仁核的基底外侧核中的主要神经元监测诱发的突触后电流。非NMDA，NMDA，GABA（A）和GABA（B）受体介导混合的突触后电流。添加到灌注培养基中的异氟烷降低了非NMDA，NMDA和GABA（B）受体激活后突触信号传导的强度，而GABA（A）受体介导的反应得到增强。神经元兴奋性的总体降低还反映在场电位振幅的降低中。异氟烷既没有改变膜的静息电位，也没有改变杏仁核中主要神经元的输入阻力。目前的结果可能有助于了解在全身麻醉下如何抑制应激反应和持久的神经塑性过程。

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