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首页> 外文期刊>The European Journal of Neuroscience >Cyclin S: a new member of the cyclin family plays a role in long-term memory.
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Cyclin S: a new member of the cyclin family plays a role in long-term memory.

机译：细胞周期蛋白S：细胞周期蛋白家族的新成员在长期记忆中发挥作用。

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摘要

Memory is thought to be subserved by structural and functional alteration in synaptic connectivity. But although neuronal plasticity requires gene expression, the identity of the proteins involved is largely unknown. Using the chick 1-day-old passive avoidance learning paradigm and differential display RNA fingerprinting, we identified 13 candidate genes which are upregulated in the intermediate medial hyperstriatum ventrale (IMHV), an area that has been correlated with the initial processing of memory formation. One of the induced genes is a new member of the cyclin family, with high homology to cyclin L (ania-6a). Analysis of the expression pattern of this gene after training revealed two time waves of induction: the first correlated with learning and initial memory process in the IMHV; the second correlated with memory consolidation, first in the IMHV, and then in the lobus paraolefactoris. There is a correlation between methylanthranilate (MeA) concentrations (the malaise substrate in the passive avoidance training procedure), the duration of memory and the expression level of cyclin S. While training chicks on low concentrations of MeA causes short-term memory and low expression level of cyclin S, high concentration of MeA induces long-term memory and high expression level of cyclin S in the IMHV. The role of cyclins in the regulation of neuronal-plasticity-related gene expression was overlooked, and it might serve as a key step in long-term memory formation.
机译：记忆被认为通过突触连通性的结构和功能改变来保留。但是，尽管神经元可塑性需要基因表达，但所涉及的蛋白质的身份在很大程度上尚不清楚。使用雏鸡1天大的被动回避学习范例和差异显示RNA指纹图谱，我们鉴定了13个候选基因，这些基因在中间内侧纹状体腹侧（IMHV）中上调，IMHV是与记忆形成的初始过程相关的区域。诱导的基因之一是细胞周期蛋白家族的新成员，与细胞周期蛋白L（ania-6a）具有高度同源性。训练后对该基因表达模式的分析揭示了两个诱导时间波：第一个与IMHV中的学习和初始记忆过程相关;第二个原因与记忆巩固有关，首先是在IMHV中，然后是在脑旁绒毛膜炎。甲基邻氨基苯甲酸（MeA）浓度（被动回避训练过程中不适的底物），记忆力的持续时间和细胞周期蛋白S的表达水平之间存在相关性。以低浓度的MeA训练雏鸡会导致短期记忆和低表达细胞周期蛋白S水平升高，高浓度MeA诱导IMHV中细胞周期蛋白S的长期记忆和高表达水平。细胞周期蛋白在调节神经元可塑性相关基因表达中的作用被忽略了，它可能是长期记忆形成的关键步骤。

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