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首页> 外文期刊>The European Journal of Neuroscience >The frontal predominance in human EEG delta activity after sleep loss decreases with age.
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The frontal predominance in human EEG delta activity after sleep loss decreases with age.

机译：睡眠丧失后，人类脑电图三角洲活动的前沿优势随年龄的增长而降低。

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Abstract Sleep loss has marked and selective effects on brain wave activity during subsequent recovery sleep. The electroencephalogram (EEG) responds to sleep deprivation with a relative increase in power density in the delta and theta range during non-rapid eye movement sleep. We investigated age-related changes of the EEG response to sleep deprivation along the antero-posterior axis (Fz, Cz, Pz, Oz) under constant routine conditions. Both healthy young (20-31 years) and older (57-74 years) participants manifested a significant relative increase in EEG power density in the delta and theta range after 40 h of sleep deprivation, indicating a sustained capacity of the sleep homeostat to respond to sleep loss in ageing. However, the increase in relative EEG delta activity (1.25-3.75 Hz) following sleep deprivation was significantly more pronounced in frontal than parietal brain regions in the young, whereas such a frontal predominance was diminished in the older volunteers. This age-related decrease of frontal delta predominance was most distinct at the beginning of the recovery sleep episode. Furthermore, the dissipation of homeostatic sleep pressure during the recovery night, as indexed by EEG delta activity, exhibited a significantly shallower decline in the older group. Activation of sleep regulatory processes in frontal brain areas by an extension of wakefulness from 16 to 40 h appears to be age-dependent. These findings provide quantitative evidence for the hypothesis that frontal brain regions are particularly vulnerable to the effects of elevated sleep pressure ('prefrontal tiredness') and ageing ('frontal ageing').
机译：摘要睡眠丧失对随后的恢复睡眠期间的脑电波活动具有明显的选择性影响。脑电图（EEG）在非快速眼动睡眠期间对睡眠剥夺作出反应，其功率密度在δ和θ范围内相对增加。我们调查了在恒定的常规条件下，沿前-后轴（Fz，Cz，Pz，Oz）对睡眠剥夺的脑电图反应与年龄相关的变化。健康的年轻参与者（20-31岁）和年龄较大（57-74岁）的参与者在睡眠剥夺40 h后，在δ和theta范围内均表现出EEG功率密度的显着相对增加，表明睡眠稳压器具有持续的反应能力在衰老中睡眠不足。然而，在年轻人中，睡眠剥夺后相对EEGδ活性的增加（1.25-3.75 Hz）在额叶中比在顶脑区中更为明显，而在较年长的志愿者中，这种额叶优势被减弱了。在恢复性睡眠发作开始时，这种与年龄相关的额叶优势占主导地位的下降最为明显。此外，以EEGδ活性为指标的康复夜晚消散体内稳态睡眠压力的现象在老年人群中表现出明显较浅的下降。通过将觉醒时间从16小时延长至40小时，激活额叶大脑区域的睡眠调节过程似乎与年龄有关。这些发现为额叶大脑区域特别容易受到睡眠压力升高（“额叶疲倦”）和衰老（“额叶衰老”）的影响提供了定量证据。

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