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首页> 外文期刊>The European Journal of Neuroscience >Behavioural parameters in aged rats are related to LTP and gene expression of ChAT and NMDA-NR2 subunits in the striatum.
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Behavioural parameters in aged rats are related to LTP and gene expression of ChAT and NMDA-NR2 subunits in the striatum.

机译：老年大鼠的行为参数与纹状体中LTP以及ChAT和NMDA-NR2亚基的基因表达有关。

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摘要

Abstract Striatal parameters were assessed for their relevance to age-related behavioural decline. Forty aged rats (28-30 months) were tested in the water maze and open field. Of these, seven superior and seven inferior learners were compared with each other in terms of levels of in vitro short- and long-term potentiation (STP and LTP), and gene expression of choline acetyltransferase (ChAT) as well as of the NMDA-NR2A-C subunits assessed by quantitative RT-PCR. Results revealed that the superior as compared with the inferior learners had higher levels of ChAT mRNA in the striatum. For the superior group, ChAT mRNA was correlated with escape on to the cued platform in the water maze, whereas level of LTP was predictive of place learning in the water maze and rearing activity in the open field. For the inferior group, expression of NR2A and NR2B was positively correlated with place learning and probe trial performance in the water maze. The results show that individual differences in various behaviours of aged rats were accounted for by variability in striatal parameters, i.e. LTP, ChAT and NMDA-NR2 subunit mRNA. Notably, the correlations found were heterogeneous amid the groups, e.g. variability in place learning was explained by variability in levels of LTP in the superior learners, but in levels of NR2A-B mRNA in the inferior group.
机译：摘要评估了纹状体参数与年龄相关行为下降的相关性。在水迷宫和旷野中测试了40只衰老的大鼠（28-30个月）。其中，在体外短期和长期增强水平（STP和LTP）以及胆碱乙酰基转移酶（ChAT）和NMDA-的基因表达水平方面，对7名优等生和7名劣等生进行了比较。通过定量RT-PCR评估了NR2A-C亚基。结果显示，与下等学习者相比，上等学习者纹状体中的ChAT mRNA水平更高。对于上等组，ChAT mRNA与逃逸到水迷宫中提示平台上相关，而LTP的水平预示着迷宫中的位置学习和在旷野中的饲养活动。对于下等组，NR2A和NR2B的表达与水迷宫中的位置学习和探针试验性能呈正相关。结果表明，老年大鼠各种行为的个体差异是由纹状体参数即LTP，ChAT和NMDA-NR2亚基mRNA的变异性引起的。值得注意的是，发现的相关性在各组之间是异类的，例如上位学习者中LTP水平的差异解释了就地学习的差异，而下组中NR2A-B mRNA的差异则解释了位置学习的差异。

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