The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by Abeta and acts as a cognitive enhancer.

Mileusnic R; Lancashire CL; Rose SP

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The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by Abeta and acts as a cognitive enhancer.

机译：存在于淀粉样蛋白前体蛋白中的肽序列Arg-Glu-Arg可以防止Abeta引起的记忆丧失，并充当认知增强剂。

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Abstract Amino acid sequences containing the palindromic tripeptide RER, matching amino acids 328-330 of the amyloid precursor protein APP, when injected intracerebrally prior to or just after training, protect against memory loss induced by amyloid-beta (Abeta) in a one-trial passive avoidance task in the young chick. RER also acts as a cognitive enhancer, strengthening memory for a weak version of the task. N-terminal acylation of RER protects it against rapid degradation, and AcRER is effective in restoring memory if administered peripherally. Biotinylated RER binds to chick neuronal perikarya in an APP-displaceable manner via 66 and approximately 110 kDa neuronal cell membrane proteins. We suggest that RER binding is likely to exert effects on memory retention via receptor-mediated events that include activation of second messenger pathways. These findings suggest that RER and its derivatives may offer a novel approach to enhancing the neuroprotective effects of APP and alleviating the effects of memory loss in the early stages of Alzheimer's disease.

机译：摘要含有回文三肽RER，与淀粉样蛋白前体蛋白APP的氨基酸328-330相匹配的氨基酸序列，在训练前或训练后经脑内注射时，可以防止淀粉样蛋白-β（Abeta）在一次试验中引起的记忆力丧失雏鸡的被动回避任务。 RER还可以充当认知增强器，从而增强对任务的较弱版本的记忆。 RER的N末端酰化可防止其快速降解，并且如果外围给药，AcRER可有效恢复记忆。生物素化的RER通过66和约110 kDa的神经元细胞膜蛋白以APP可置换的方式与鸡神经元周围核结合。我们建议RER结合很可能通过受体介导的事件，包括第二信使途径的激活，对记忆保持力产生影响。这些发现表明，RER及其衍生物可能为增强APP的神经保护作用和减轻阿尔茨海默氏病早期阶段的记忆丧失提供一种新颖的方法。

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《The European Journal of Neuroscience》 |2004年第7期|共6页
作者
Mileusnic R; Lancashire CL; Rose SP;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Memory Loss; Amyloid beta-Protein Precursor; aminoacid sequence of protein; 淀粉样β蛋白前体;

机译：Memory Loss;Amyloid beta-Protein Precursor;aminoacid sequence of protein;淀粉样β蛋白前体;

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1. The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by Abeta and acts as a cognitive enhancer. [J] . Mileusnic R, Lancashire CL, Rose SP The European Journal of Neuroscience . 2004,第7期

机译：存在于淀粉样蛋白前体蛋白中的肽序列Arg-Glu-Arg可以防止Abeta引起的记忆丧失，并充当认知增强剂。
2. Biochemical studies in Normal Pressure Hydrocephalus (NPH) patients: change in CSF levels of amyloid precursor protein (APP), amyloid-beta (Abeta) peptide and phospho-tau. [J] . Ray B, Reyes PF, Lahiri DK Journal of psychiatric research . 2011,第4期

机译：常压性脑积水（NPH）患者的生化研究：淀粉样前体蛋白（APP），淀粉样β（Abeta）肽和磷酸化tau蛋白的CSF水平变化。
3. Intraneuronal amyloid precursor protein (APP) and appearance of extracellular beta-amyloid peptide (abeta) in the brain of aging kokanee salmon. [J] . Maldonado TA, Jones RE, Norris DO Journal of neurobiology . 2002,第1期

机译：神经细胞内淀粉样蛋白前体蛋白（APP）和衰老的柯卡尼鲑鱼脑中胞外β-淀粉样肽（abeta）的出现。
4. Overexpression of human amyloid precursor protein causes neurodegeneration and loss of synaptic proteins in transgenic Drosophila [C] . Sarantseva S., Bolshakova O., Timoshenko S., International Conference on Alzheimer's and Parkinson's Diseases . 2009

机译：人淀粉样蛋白前体蛋白的过度表达导致转基因果蝇中的神经变性和突触蛋白的丧失
5. Role of amyloid precursor protein and amyloid-beta in Alzheimer's disease: Modulation of APP processing detection of Abeta oligomers, and their role in the pathogenesis and treatment of AD. [D] . Kim, Minkyu Leo. 2009

机译：淀粉样前体蛋白和淀粉样β在阿尔茨海默氏病中的作用：APP处理Abeta寡聚体检测的调节及其在AD的发病机理和治疗中的作用。
6. Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila [O] . Isabelle Bourdet, Aurélie Lampin-Saint-Amaux, Thomas Preat, -1

机译：淀粉样蛋白β肽加剧果蝇中淀粉样蛋白前体蛋白功能丧失引起的记忆缺陷。
7. Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila. [O] . Isabelle Bourdet, Aurélie Lampin-Saint-Amaux, Thomas Preat, 2015

机译：淀粉样蛋白β肽加剧果蝇中淀粉样蛋白前体蛋白功能丧失引起的记忆缺陷。

The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by Abeta and acts as a cognitive enhancer.

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