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首页> 外文期刊>The European Journal of Neuroscience >Reconsolidation of fresh, remote, and extinguished fear memory in medaka: old fears don't die.
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Reconsolidation of fresh, remote, and extinguished fear memory in medaka: old fears don't die.

机译：在medaka中重新整合新鲜，遥远和已灭绝的恐惧记忆：旧的恐惧不会消失。

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摘要

Abstract Long-term fear memory in the medaka fish (Oryzias latipes) regains transient sensitivity to a consolidation blocker immediately after memory reactivation in retrieval ('reconsolidation'). Here we show that reconsolidation occurs in fresh long-term memories but not in remote memories, and that the apparent amnesia induced by blockade of reconsolidation can be reinstated by an unpaired reinforcer, a procedure that has no effect on amnesia induced by blockade of consolidation. Extinction memory also undergoes post-reactivation reconsolidation, the blockade of which exposes the previously acquired fear. Hence in medaka, the process manifested in reconsolidation seems itself to consolidate; moreover, even when the post-reactivation application of the consolidation blocker is still able to disrupt the memory, the conditioned fear does not seem to go away permanently.
机译：摘要retrieval（Oryzias latipes）鱼的长期恐惧记忆在恢复记忆（“重新整合”）后立即恢复了对巩固阻滞剂的短暂敏感性。在这里，我们表明重新巩固发生在新鲜的长期记忆中，而不是在远程记忆中发生，并且通过不成对的强化剂可以恢复由于重新巩固受阻而引起的明显的失忆症，该过程对由于巩固受阻而引起的失忆症没有影响。灭绝记忆也经历了重新激活后的巩固，其封锁暴露了先前获得的恐惧。因此，在田市，重新整合所体现的过程似乎本身就在巩固。此外，即使合并阻止程序的重新激活后应用程序仍然能够破坏内存，条件限制的恐惧似乎也不会永久消失。

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