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首页> 外文期刊>The European Journal of Neuroscience >Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone.
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Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone.

机译：多巴胺能黑质纹状体投射调节成年小鼠脑室下区的神经前体增殖。

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Abstract An understanding of the regulators of neurogenesis in the normal and diseased brain is necessary in order to recruit endogenously produced neural precursors for cell replacement in neurodegenerative disorders such as Parkinson's disease. The location of dopaminergic projections from the midbrain to the neostriatum and nucleus accumbens overlaps with the most active region of neurogenesis in the adult brain, the subventricular zone of the anterior lateral ventricle. This suggests that dopamine may contribute to regulation of the subventricular niche of adult neurogenesis. Here, we show in adult mice that destruction of the dopaminergic neurons in the substantia nigra and ventral tegmental area in a 6-hydroxydopamine model of Parkinson's disease reduced the number of proliferating neural precursors in the subventricular zone of the anterior lateral ventricle by approximately 40%. The effect on neural precursor proliferation correlated with the extent of dopaminergic denervation in the neighboring neostriatum. This identifies dopamine as one of the few known endogenous regulators of adult neurogenesis with implications for the potential use of endogenous neural precursors in cell replacement strategies for Parkinson's disease.
机译：摘要为了招募内源性产生的神经前体，用于帕金森氏病等神经退行性疾病的细胞置换，有必要了解正常和患病大脑中神经发生的调节剂。从中脑到新纹状体和伏隔核的多巴胺能投射的位置与成年脑中神经发生最活跃的区域（前侧脑室的脑室下区域）重叠。这表明多巴胺可能有助于调节成人神经发生的脑室下位。在这里，我们在成年小鼠中发现，帕金森氏病6-羟基多巴胺模型中黑质和腹侧被盖区的多巴胺能神经元的破坏使前侧脑室下室区的增殖神经前体数量减少了40％ 。对神经前体增殖的影响与邻近新纹状体中多巴胺能神经支配的程度相关。这将多巴胺确定为成人神经发生的少数已知内源性调节剂之一，这暗示着内源性神经前体在帕金森氏病细胞替代策略中的潜在用途。

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