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首页> 外文期刊>The European Journal of Neuroscience >Input and frequency-specific entrainment of postsynaptic firing by IPSPs of perisomatic or dendritic origin.
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Input and frequency-specific entrainment of postsynaptic firing by IPSPs of perisomatic or dendritic origin.

机译：过异源性或树突状来源的IPSP对突触后放电的输入和频率特异性夹带。

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摘要

Abstract Correlated activity of cortical neurons underlies cognitive processes. Networks of several distinct classes of gamma-aminobutyric acid (GABA)ergic interneurons are capable of synchronizing cortical neurons at behaviourally relevant frequencies. Here we show that perisomatic and dendritic GABAergic inputs provided by two classes of GABAergic cells, fast spiking and bitufted interneurons, respectively, entrain the timing of postsynaptic spikes differentially in both pyramidal cells and interneurons at beta and gamma frequencies. Entrainment of pyramidal as well as regular spiking non-pyramidal cells was input site and inhibitory postsynaptic potential frequency dependent. Gamma frequency input from fast spiking cells entrained pyramidal cells on the positive phase of an intrinsic cellular theta oscillation, whereas input from bitufted cells was most effective in gamma frequency entrainment on the negative phase of the theta oscillation. The discharge of regular spiking interneurons was phased atgamma frequency by dendritic input from bitufted cells, but not by perisomatic input from fast spiking cells. Action potentials in fast spiking GABAergic neurons were phased at gamma frequency by both other fast spiking and bitufted cells, regardless of whether the presynaptic GABAergic input was at gamma or beta frequency. The interaction of cell type-specific intrinsic properties and location-selective GABAergic inputs could result in a spatio-temporally regulated synchronization and gating of cortical spike propagation in the network.
机译：摘要皮质神经元的相关活动是认知过程的基础。几种不同类别的γ-氨基丁酸（GABA）能中神经元的网络能够以行为相关的频率同步皮质神经元。在这里，我们显示了由两类GABA能细胞分别提供的过饱和和树突状GABA能输入，分别是快速尖峰和咬合的中间神经元，它们分别以β和γ频率夹带锥体细胞和中间神经元突触后尖峰的时间。锥体细胞和常规刺突的非锥体细胞的夹带是输入位点和抑制性突触后电位频率依赖性。来自快速刺突细胞的伽马频率输入在固有细胞theta振荡的正相上夹带锥体细胞，而来自咬合细胞的输入在theta振荡的负相位上的gamma频率夹带中最有效。规则尖峰中间神经元的放电在一定频率上是通过咬合细胞的树突状输入而定的，而不是通过快速尖峰细胞的过各向异性输入而定的。快速突入的GABA能神经元的动作电位被其他快速突入和咬合的细胞以γ频率相控，无论突触前的GABA能神经输入是处于γ还是β频率。细胞类型特有的内在特性和位置选择性GABA能输入之间的相互作用可能导致时空调节的同步和网络中皮层尖峰传播的门控。

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