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首页> 外文期刊>The European Journal of Neuroscience >Decreased histamine H receptor binding in the brain of depressed patients.
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Decreased histamine H receptor binding in the brain of depressed patients.

机译：抑郁症患者大脑中组胺H受体的结合减少。

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Abstract The central histaminergic neuron system modulates the wakefulness, sleep-awake cycle, appetite control, learning and memory, and emotion. Previous studies have reported changes in neuronal histamine release and its metabolism under stress conditions in the mammalian brain. In this study, we examined, using positron emission tomography (PET) and [(11)C]-doxepin, whether the histaminergic neuron system is involved in human depression. Cerebral histamine H1 receptor (H(1)R) binding was measured in 10 patients with major depression and in 10 normal age-matched subjects using PET and [(11)C]-doxepin. Data were calculated by a graphical analysis on voxel-by-voxel and ROI (region of interests) basis. Binding potential (BP) values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. There was no area of the brain where [(11)C]-doxepin binding was significantly higher in the depressed patients than in the controls. ROI-based analysis also revealed that BP values for [(11)C]-doxepin binding in the frontal cortex and cingulate gyrus decreased in proportion to self-rating depressive scales scores. The results of this study demonstrate that depressed patients have decreased brain H(1)R binding and that this decrease correlates with the severity of depression symptoms. It is therefore suggested that the histaminergic neuron system plays an important role in the pathophysiology of depression and that its modulation may prove to be useful in the treatment of depression.
机译：摘要中枢组胺能神经元系统调节清醒，觉醒周期，食欲控制，学习和记忆以及情绪。先前的研究报道了哺乳动物脑在应激条件下神经元组胺释放及其代谢的变化。在这项研究中，我们使用正电子发射断层扫描（PET）和[（11）C] -doxepin检查了组胺能神经元系统是否参与了人的抑郁症。使用PET和[（11）C] -doxepin在10例重度抑郁症患者和10例年龄匹配的正常受试者中测量了脑组胺H1受体（H（1）R）的结合。数据通过逐像素和ROI（感兴趣区域）的图形分析进行计算。在抑郁症患者中，额叶和前额叶皮质中的[（11）C]-多塞平结合的结合电位（BP）值显着低于正常对照组。在抑郁症患者中，没有大脑区域[（11）C]-多塞平结合明显高于对照组。基于ROI的分析还显示，额叶皮层和扣带回中的[（11）C]-多塞平结合的BP值与自评抑郁量表分数成比例下降。这项研究的结果表明，抑郁症患者的脑H（1）R结合力降低，而这种降低与抑郁症症状的严重程度相关。因此，建议组胺能神经元系统在抑郁症的病理生理学中起重要作用，并且其调节可证明对抑郁症的治疗有用。

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