...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >A novel role for polyamines in adult neurogenesis in rodent brain.
【24h】

A novel role for polyamines in adult neurogenesis in rodent brain.

机译：多胺在啮齿动物脑中成年神经发生中的新作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Although neurogenesis in the adult is known to be regulated by various internal cues such as hormones, growth factors and cell-adherence molecules, downstream elements underlying their action at the cellular level still remain unclear. We previously showed in an insect model that polyamines (putrescine, spermidine and spermine) play specific roles in adult brain neurogenesis. Here, we demonstrate their involvement in the regulation of secondary neurogenesis in the rodent brain. Using neurosphere assays, we show that putrescine addition stimulates neural progenitor proliferation. Furthermore, in vivo depletion of putrescine by specific and irreversible inhibition of ornithine decarboxylase, the first key enzyme of the polyamine synthesis pathway, induces a consistent decrease in neural progenitor cell proliferation in the two neurogenic areas, the dentate gyrus and the subventricular zone. The present study reveals common mechanisms underlying birth of new neurons in vertebrate and invertebratespecies.
机译：摘要尽管已知成人中的神经发生受到各种内部线索的调节，例如激素，生长因子和细胞粘附分子，但在细胞水平上起作用的下游元素仍然不清楚。我们之前在昆虫模型中证明，多胺（氨基乙酸，氨基乙酸，亚精胺和亚精胺）在成人脑神经发生中起特定作用。在这里，我们证明了它们参与了啮齿动物大脑中次级神经发生的调控。使用神经球测定，我们显示腐胺添加刺激神经祖细胞增殖。此外，通过特异性和不可逆地抑制鸟氨酸脱羧酶（多胺合成途径的第一个关键酶）在体内消耗腐胺，导致两个神经源性区域（齿状回和脑室下区域）神经祖细胞增殖的持续减少。本研究揭示了脊椎动物和无脊椎动物物种中新神经元诞生的常见机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号