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首页> 外文期刊>The European Journal of Neuroscience >Topography of cortico-striatal connections in man: anatomical evidence for parallel organization.
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Topography of cortico-striatal connections in man: anatomical evidence for parallel organization.

机译：人的皮质-纹状体连接的地形：平行组织的解剖学证据。

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Abstract Tracing studies in non-human primates support the existence of several parallel neuronal circuits involving cerebral cortex, basal ganglia and thalamus. Distinct functional loops were proposed to underlie multiple aspects of normal and pathological behaviour in man. We present here the first anatomical evidence for separate corticostriatal systems in humans. Neural connections of the sensorimotor and prefrontal cortex to the striatum were studied in one human brain using the Nauta method for anterogradely degenerating axons. Axons originating from a lesion in the left sensorimotor cortex, including the face area, were found to terminate in the superolateral part of the ipsilateral putamen, forming a narrow band in its posterior part. Inside the band, the distribution of degenerating axons was inhomogeneous; high-density clusters of approximately 2.5 mm in diameter were separated by regions with less dense cortical projections. Axons originating from a small lesion in the fundus of the right superior frontal sulcus were found in the upper part of the ipsilateral caudate nucleus. The existence of discrete and anatomically segregated terminal patches originating from distinct cortical regions suggests parallel organization of cortico-striatal connections in man.
机译：摘要在非人类灵长类动物中进行的追踪研究支持了涉及大脑皮层，基底神经节和丘脑的多个平行神经元回路的存在。有人提出了明显的功能循环，作为人类正常和病理行为的多个方面的基础。我们在这里提出了人类分离皮质皮质系统的第一个解剖学证据。使用Nauta方法顺行变性轴突在一个人脑中研究了感觉运动和前额叶皮层与纹状体的神经联系。发现源自左感觉运动皮层病变的轴突（包括面部区域）终止于同侧壳状核的上外侧部分，在其后部形成一条窄带。在带内，退化轴突的分布是不均匀的。直径约2.5mm的高密度簇被皮质密度较小的区域隔开。在同侧尾状核的上部发现了源自右上额额沟眼底小病变的轴突。源于不同皮质区域的离散的，解剖学上分离的末端斑块的存在表明人类皮质-纹状体连接的平行组织。

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