...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Corticofugal feedback for auditory midbrain plasticity elicited by tones and electrical stimulation of basal forebrain in mice.
【24h】

Corticofugal feedback for auditory midbrain plasticity elicited by tones and electrical stimulation of basal forebrain in mice.

机译：小鼠的基底前脑的音调和电刺激引起的听觉性大脑皮质可塑性反馈。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The auditory cortex (AC) is the major origin of descending auditory projections and is one of the targets of the cholinergic basal forebrain, nucleus basalis (NB). In the big brown bat, cortical activation evokes frequency-specific plasticity in the inferior colliculus and the NB augments this collicular plasticity. To examine whether cortical descending function and NB contributions to collicular plasticity are different between the bat and mouse and to extend the findings in the bat, we induced plasticity in the central nucleus of the mouse inferior colliculus by a tone paired with electrical stimulation of the NB (hereafter referred to as tone-ES(NB)). We show here that tone-ES(NB) shifted collicular best frequencies (BFs) towards the frequency of the tone paired with ES(NB) when collicular BFs were different from tone frequency. The shift in collicular BF was linearly correlated to the difference between collicular BFs and tone frequencies. The changes in collicular BFs after tone-ES(NB) were similar to those found in the big brown bat. Compared with cortical plasticity evoked by tone-ES(NB), the pattern of collicular BF shifts was identical but the shifting range of collicular BFs was narrower. A GABA(A) agonist (muscimol) or a muscarinic acetylcholine receptor antagonist (atropine) applied to the AC completely abolished the collicular plasticity evoked by tone-ES(NB). Therefore, our findings strongly suggest that the AC plays a critical role in experience-dependent auditory plasticity through descending projections.
机译：听觉皮层（AC）是下降的听觉投影的主要来源，并且是胆碱能基底前脑，基底核（NB）的目标之一。在大棕蝙蝠中，皮层激活引起下丘的特定频率的可塑性，而NB增强了这种胶质的可塑性。为了检查蝙蝠与小鼠之间的皮质下降功能和NB对胶质可塑性的贡献是否不同，并且为了扩展蝙蝠的发现，我们通过与NB的电刺激配对的音调在小鼠下丘脑中央核中诱导了可塑性。 （以下称为音调ES（NB））。我们在这里显示，当胶体BF与音调频率不同时，音调ES（NB）将胶体最佳频率（BFs）移向与ES（NB）配对的音调频率。胶质BF的变化与胶质BF和音调频率之间的线性相关。音调-ES（NB）后，胶态BF的变化与大棕蝙蝠相似。与音调-ES（NB）诱发的皮质可塑性相比，胶体BF的移动模式相同，但胶体BF的移动范围更窄。应用于AC的GABA（A）激动剂（muscimol）或毒蕈碱型乙酰胆碱受体拮抗剂（阿托品（atropine））完全消除了口气ES（NB）引起的胶质可塑性。因此，我们的发现有力地表明，通过递减的预测，AC在依赖于经验的听觉可塑性中起着至关重要的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号