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首页> 外文期刊>The European Journal of Neuroscience >RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour.
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RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour.

机译：RSEP1是一种新型基因，在神经性疼痛行为中具有功能性参与。

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摘要

Neuropathic pain from nerve injury by trauma, disease or surgery often causes prolonged suffering. To explore the molecular mechanisms that underlie neuropathic pain, we used mRNA from the L4-5 segments of the lumbar spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain, and differentially screened a cDNA library from the rat brain. A novel gene, termed RSEP1 (Rat Spinal cord Expression Protein 1), was identified. Northern blots revealed that RSEP1 was expressed mainly in the central nervous system including the cerebral cortex, hippocampus, brainstem and spinal cord, as well as in the kidney and ovary. In situ hybridization showed a high level of RSEP1 expression in the CA1, CA3 and dentate gyrus regions of the hippocampus and the small sensory neurons in the dorsal horn, as well as the large neurons in the ventral horn of the spinal cord. Intrathecal injection of RSEP1 antisense oligonucleotide into the spinal cord lumbar enlargement attenuated neuropathic pain behaviours in CCI rats, suggesting a functional involvement of RSEP1 in neuropathic pain.
机译：由创伤，疾病或手术引起的神经损伤引起的神经性疼痛通常会导致长期的痛苦。为了探索神经病理性疼痛的分子机制，我们使用了慢性收缩损伤（CCI）引起的神经性疼痛的大鼠腰脊髓L4-5片段的mRNA，并从大鼠脑中差异筛选了一个cDNA文库。确定了一个新基因，称为RSEP1（大鼠脊髓表达蛋白1）。 Northern印迹显示，RSEP1主要在中枢神经系统中表达，包括大脑皮层，海马，脑干和脊髓，以及在肾脏和卵巢中。原位杂交显示在海马CA1，CA3和齿状回区域以及背角的小感觉神经元以及脊髓腹角的大神经元中高水平的RSEP1表达。鞘内注射RSEP1反义寡核苷酸到脊髓腰椎肿大减轻了CCI大鼠的神经性疼痛行为，表明RSEP1在神经性疼痛中有功能性参与。

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