Synaptic plasticity in the absence of backpropagating spikes of layer II inputs to layer V pyramidal cells in rat visual cortex.

Stiefel KM; Tennigkeit F; Singer W

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Synaptic plasticity in the absence of backpropagating spikes of layer II inputs to layer V pyramidal cells in rat visual cortex.

机译：在没有向大鼠视皮层中的第V层锥体细胞输入的第II层反向传播尖峰的情况下，突触可塑性。

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Abstract Use-dependent changes of synaptic transmission are thought to depend on the evaluation of temporal correlations between pre- and postsynaptic excitatory activity. Previous studies have demonstrated long-term potentiation (LTP) in layer V pyramidal cells after coincident pairing of presynaptic excitatory input with postsynaptic depolarizations, evoking backpropagating action potentials (BAPs). Here we paired excitatory layer II input with somatic hyperpolarization, which blocked BAPs in layer V pyramidal cells of rat visual cortex and induced reliable long-term depression (LTD). Upon cholinergic receptor activation, this BAP-independent protocol also induced LTP, which was not dependent on N-methyl-d-aspartate receptor activation, but blocked by metabotropic glutamate receptor (mGluR) antagonists.

机译：摘要突触传递的依赖于用途的变化被认为取决于对突触前和突触后兴奋活动之间的时间相关性的评估。先前的研究表明，在突触前兴奋性输入与突触后去极化同时配对，产生反向传播动作电位（BAP）后，V层锥体细胞中的长期增强（LTP）。在这里，我们将兴奋性第II层输入与体细胞超极化配对，后者阻止了大鼠视皮层V层锥体细胞中的BAP，并诱导了可靠的长期抑郁症（LTD）。胆碱能受体激活后，这种与BAP无关的方案也诱导了LTP，LTP不依赖于N-甲基-d-天冬氨酸受体的激活，但被代谢型谷氨酸受体（mGluR）拮抗剂阻断。

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《The European Journal of Neuroscience》 |2005年第9期|共6页
作者
Stiefel KM; Tennigkeit F; Singer W;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Pyramidal Cells; Visual Cortex; plasticity; 锥体细胞; 视皮质;

机译：Pyramidal Cells;Visual Cortex;plasticity;锥体细胞;视皮质;

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1. Synaptic plasticity in the absence of backpropagating spikes of layer II inputs to layer V pyramidal cells in rat visual cortex. [J] . Stiefel KM, Tennigkeit F, Singer W The European Journal of Neuroscience . 2005,第9期

机译：在没有向大鼠视皮层中的第V层锥体细胞输入的第II层反向传播尖峰的情况下，突触可塑性。
2. Loss of Visually Driven Synaptic Responses in Layer 4 Regular-Spiking Neurons of Rat Visual Cortex in Absence of Competing Inputs [J] . Giuliano Iurilli, Fabio Benfenati Paolo Medini Cerebral cortex . 2012,第9期

机译：在缺少竞争性输入的情况下，大鼠视觉皮层的第4层规则加标神经元的视觉驱动突触反应丧失
3. Loss of Visually Driven Synaptic Responses in Layer 4 Regular-Spiking Neurons of Rat Visual Cortex in Absence of Competing Inputs [J] . Giuliano Iurilli Fabio Benfenati and Paolo Medini Cerebral Cortex . 2012,第9期

机译：在缺乏竞争性输入的情况下，大鼠视皮层的第4层规则突触神经元中的视觉驱动突触反应丧失
4. Gamma-Frequency Synaptic Input Enhances Gain Modulation of the Layer V Pyramidal Neuron Model [C] . Xiumin Li, Kenji Morita, Hugh P.C. Robinson, Advances in cognitive neurodynamics (II) . 2011

机译：伽玛频率突触输入增强了V层金字塔形神经元模型的增益调制。
5. An in vitro electrophysiologic analysis of the effect of nicotinic receptor activation on synaptic transmission and membrane properties in layer II--III rat auditory cortex. [D] . Jebelli, Azadeh Kokabi. 2006

机译：烟碱样受体激活对II-III层大鼠听觉皮层突触传递和膜特性的影响的体外电生理分析。
6. Input Specificity and Dependence of Spike Timing–Dependent Plasticity on Preceding Postsynaptic Activity at Unitary Connections between Neocortical Layer 2/3 Pyramidal Cells [O] . Misha Zilberter, Carl Holmgren, Isaac Shemer, -1

机译：输入特异性和穗定时的依赖性—在新皮质层2/3金字塔形细胞之间的整体连接上先于突触后活动的可塑性。
7. Loss of Visually Driven Synaptic Responses in Layer 4 Regular-Spiking Neurons of Rat Visual Cortex in Absence of Competing Inputs [O] . G. Iurilli, F. Benfenati, P. Medini 2011

机译：在没有竞争输入的情况下，大鼠视觉皮层常规尖峰神经元的视觉驱动突触反应的丧失
8. Synaptic Plasticity in Visual Cortex. From Synaptic Properties to Membranes andReceptors [R] . Cooper, L. N. 1995

机译：视觉皮层中的突触可塑性。从突触属性到膜和受体

Synaptic plasticity in the absence of backpropagating spikes of layer II inputs to layer V pyramidal cells in rat visual cortex.

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