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首页> 外文期刊>The European Journal of Neuroscience >Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior.
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Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior.

机译：压力对运动功能的调节：压力和皮质酮对行为影响的新概念。

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Stress and stress hormones affect a variety of behaviors and cognitive abilities. The influences of stress and glucocorticoids on motor function, however, have not been characterized although the presence of glucocorticoid receptors in the motor system has been documented. Here we demonstrate that stress and the stress hormone corticosterone influence motor system function in rats. Groups of adult female Long-Evans rats underwent either a daily stress-inducing procedure (immobilization or swimming in cold water) or oral corticosterone treatment. While these treatments continued, animals were tested in skilled reaching and skilled walking tasks for a period of 2 weeks. Both acute (day 1) and chronic (day 14) stress and corticosterone treatment reduced skilled movement accuracy in reaching and walking and increased performance speed. Furthermore, both chronic stress and chronic corticosterone treatment altered skilled movement patterns in the reaching task. These findings indicate that stress modulates motor system function and that these effects are partially mediated by glucocorticoids. To examine whether stress-induced changes might also derive from enhanced emotionality, rats were treated with the benzodiazepine diazepam. Based on an inverted U-shaped dose-response relationship, a moderate dose of diazepam significantly improved reaching success while at the same time reducing corticosterone levels. Thus, stress-associated emotional responses such as anxiety might account for diminished movement accuracy. These results suggest that stress affects the motor system both directly via hormonal changes and indirectly via changes in emotionality. These findings are discussed with respect to the role of stress in motor system function and movement disorders.
机译：压力和压力荷尔蒙会影响多种行为和认知能力。尽管已记录了运动系统中存在糖皮质激素受体，但尚未表征出压力和糖皮质激素对运动功能的影响。在这里，我们证明压力和压力激素皮质酮影响大鼠的运动系统功能。成年雌性Long-Evans雌性大鼠的组每天进行诱导压力的程序（固定或在冷水中游泳）或口服皮质酮治疗。在继续进行这些治疗的同时，对动物进行了技能熟练的伸手和熟练的步行任务测试，持续2周。急性（第1天）和慢性（第14天）压力和皮质酮治疗均降低了到达和行走时熟练的运动准确性，并提高了运动速度。此外，慢性压力和慢性皮质酮治疗均改变了伸手的任务中熟练的运动方式。这些发现表明，压力调节运动系统功能，这些作用部分由糖皮质激素介导。为了检查压力引起的变化是否也可能源于情绪增强，对大鼠进行了苯二氮卓地西epa治疗。基于倒U形剂量反应关系，适量地西epa可显着改善达到成功的效果，同时降低皮质酮水平。因此，与压力相关的情绪反应（如焦虑症）可能会导致运动准确性下降。这些结果表明，压力直接通过荷尔蒙变化而直接影响情绪系统，并且通过情绪变化间接地影响运动系统。讨论了有关压力在运动系统功能和运动障碍中的作用的这些发现。

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