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首页> 外文期刊>The European Journal of Neuroscience >Effects of systemically administered cocaine on sensory responses to peri-threshold vibrissae stimulation: individual cells, ensemble activity, and animal behaviour.
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Effects of systemically administered cocaine on sensory responses to peri-threshold vibrissae stimulation: individual cells, ensemble activity, and animal behaviour.

机译：全身性注射可卡因对阈值触须刺激的感官反应的影响：单个细胞，整体活动和动物行为。

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Previous studies have shown that systemic administration of cocaine transiently alters stimulus-evoked responses of ventral posteromedial (VPM) thalamic neurons. Results from these single-unit electrophysiological studies revealed that cocaine was equally likely to augment or attenuate the magnitude of sensory evoked responses following threshold level stimulation of peripheral receptive fields. In an attempt to clarify the impact of cocaine administration on sensory signal processing, we examined the drug's effects on responses of individual neurons and ensembles of VPM thalamic neurons to sensory stimuli, and performance of subjects in a sensory detection behavioural task. Extracellular responses of single (n = 1 cell/rat) or multiple VPM thalamic neurons (n = 10-40 cells/rat) were monitored before and after cumulative doses of cocaine (0.25-2.0 mg/kg i.v.). Neuronal responses were characterized by assessing the response profile to a range of peri-threshold-level deflections of the optimal whisker onthe contralateral face. Drug effects on stimulus-response curves, determined from quantitative analysis of spike train data, indicated that whereas cocaine elicits variable effects at the single cell level, the stimulus-evoked response of the recorded population was likely to increase following lower (0.25-1.0 mg/kg i.v.) doses of cocaine. Furthermore, cocaine preferentially enhanced responses to smaller magnitude deflections of vibrissa, altering the response profile from a mode that accurately conveyed stimulus strength to one that increased detection at the expense of discrimination. Finally, a similar pattern emerged in a behavioural paradigm involving rats trained to detect variable amplitude whisker pad stimulation, suggesting a common action of cocaine that may contribute to the drug's addictive properties.
机译：先前的研究表明，可卡因的全身性给药可暂时改变腹膜后内侧（VPM）丘脑神经元的刺激诱发反应。这些单单元电生理研究的结果表明，在阈值水平刺激周围感受野后，可卡因同样有可能增加或减弱感觉诱发反应的幅度。为了阐明可卡因给药对感觉信号处理的影响，我们研究了该药物对单个神经元和VPM丘脑神经元对感觉刺激的反应以及对象在感觉检测行为任务中的表现的影响。在累积剂量的可卡因（0.25-2.0 mg / kg i.v.）之前和之后监测单个（n = 1个细胞/大鼠）或多个VPM丘脑神经元（n = 10-40个细胞/大鼠）的细胞外反应。通过评估对侧脸部最佳晶须的阈值水平偏斜范围的响应曲线来表征神经元响应。根据刺激序列数据的定量分析确定，药物对刺激反应曲线的影响表明，尽管可卡因在单细胞水平上引起可变作用，但记录的种群的刺激诱发反应在降低（0.25-1.0 mg后可能会增加）。 / kg iv）可卡因剂量。此外，可卡因优先提高了对触须较小幅度偏斜的响应，从而将响应曲线从一种模式准确地传递了刺激强度改变为一种以辨别为代价提高检测强度的模式。最后，在行为范式中出现了类似的模式，其中涉及训练有素的大鼠以检测可变幅度的晶须垫刺激，表明可卡因的共同作用可能有助于药物的成瘾性。

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