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首页> 外文期刊>The European Journal of Neuroscience >Nestin-expressing cells and their relationship to mitotically active cells in the subventricular zones of the adult rat.
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Nestin-expressing cells and their relationship to mitotically active cells in the subventricular zones of the adult rat.

机译：成年大鼠心室下区表达巢蛋白的细胞及其与有丝分裂活跃细胞的关系。

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摘要

Nestin is a protein that is thought to be expressed in neural stem cells; however, there is a paucity of data on nestin expression in vivo, and little is known of the relationship between nestin and mitotically active cell populations in the subventricular zones (SVZ). In this study, the subventricular zone of the third ventricle contained a high proportion of cells that expressed nestin, while there were significantly fewer cells that expressed nestin in the SVZ of the lateral ventricles. In contrast, bromodeoxyuridine (BrdU) immunoreactivity was the diametric opposite, being higher in the SVZ of the lateral ventricle than in the SVZ of the third ventricle. Morphological and anatomical evidence suggests that nestin-expressing cells in these two areas may be different cell types. In a separate set of experiments, an acute localized lesion was induced adjacent to one of the ventricles. While the number of BrdU cells and Ki-67 cells in the SVZs increased with this manipulation, the number of nestin-expressing cells did not change significantly. These data indicate that the expression of nestin does not correlate with mitotic activity in cells of the SVZs under either normal or inflammatory conditions. It is hypothesized that nestin-expressing cells in the SVZs may give way to transit amplifying cells that in turn give way to immature neurons or glia. These transit-amplifying cells may have a much higher rate of mitosis than nestin-positive cells and may react to neural damage by increasing their rate of proliferation.
机译：Nestin是一种蛋白质，被认为在神经干细胞中表达。然而，关于体内巢蛋白表达的数据很少，对巢蛋白与脑室下区域（SVZ）中有丝分裂活跃细胞群之间关系的了解甚少。在这项研究中，第三脑室的室下区域包含大量表达巢蛋白的细胞，而在侧脑室的SVZ中表达巢蛋白的细胞明显减少。相反，溴脱氧尿苷（BrdU）的免疫反应性却截然相反，在侧脑室SVZ中高于在第三脑室SVZ中。形态和解剖学证据表明，这两个区域中表达巢蛋白的细胞可能是不同的细胞类型。在另一组实验中，邻近一个脑室诱发了急性局部病变。通过这种操作，虽然SVZ中BrdU细胞和Ki-67细胞的数量增加了，但表达巢蛋白的细胞的数量却没有明显变化。这些数据表明在正常或炎症条件下，巢蛋白的表达与SVZs细胞中的有丝分裂活性均不相关。据推测，SVZs中表达巢蛋白的细胞可能让位于转运放大细胞，而后者又让位于未成熟的神经元或神经胶质。这些转运放大细胞可能比巢蛋白阳性细胞具有更高的有丝分裂率，并可能通过增加其增殖率对神经损伤做出反应。

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